Stuart Friess, M.D.

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Associate Professor of Pediatrics, Critical Care Medicine
Critical Care Medicine

phone: (314) 454-2527

Clinical Interests

Dr. Friess is a board certified pediatric intensivist with both a research and clinical specialization in traumatic brain injury and neurocritical care.


  • BS, Brown University 1995
  • MD, Mount Sinai School of Medicine of NYU 1999


  • Internship and Residency, Pediatrics, Mount Sinai Hospital, NY, NY1999 - 2002
  • Chief Resident, Mount Sinai Hospital 2002 - 2003
  • Fellow , The Children’s Hospital of Philadelphia2003 - 2006

Licensure and Board Certification

  • PA
  • NY
  • MO
  • 2003 - PresAmerican Board of Pediatrics (renewed 2012)
  • 2006American Board of Pediatrics, Sub-board of Pediatric Critical Care Medicine

Honors and Awards

  • Sigma Xi Honor Society1994
  • Tau Beta Pi Engineering Honor Society1995
  • Mount Sinai School of Medicine Dr. Morris Bender Family Award in the Neurosciences1997
  • Alpha Omega Alpha Honor Society1998
  • Mount Sinai School of Medicine Bela Schick Pediatric Society Prize for Excellence in Pediatrics1999
  • NIH Pediatric Research Loan Repayment Program recipient2006 - 2014
  • Society of Critical Care Medicine CPR Specialty Award2014
  • Society of Critical Care Medicine Pediatrics Section Travel Grant2014
  • Member, Society for Pediatric Research2015 - Pres
  • Star Research Presentation Award, Society of Critical Care Medicine Annual Congress2016
  • Lecturer of the Month SLCH pedaitric residency program2017

Recent Publications view all (78)

Publication Co-Authors

  1. Innate and peripheral immune alterations after TBI are regulated in a gut microbiota-dependent manner in mice. J Neurotrauma. 2022. PMID:36259455 
  2. Recombinant human erythropoietin induces neuroprotection, activates MAPK/CREB pathway, and rescues fear memory after traumatic brain injury with delayed hypoxemia in mice. Brain Res. 2022;148074. PMID:36075467 
  3. The Temporal Association of the COVID-19 Pandemic and Pediatric Cardiopulmonary Resuscitation Quality and Outcomes. Pediatr Crit Care Med. 2022. PMID:36053072 
  4. Association of Blood-Based Brain Injury Biomarker Concentrations With Outcomes After Pediatric Cardiac Arrest. JAMA Netw Open. 2022;5(9):e2230518. PMID:36074465 
  5. Sodium Bicarbonate Use During Pediatric Cardiopulmonary Resuscitation: A Secondary Analysis of the ICU-RESUScitation Project Trial. Pediatr Crit Care Med. 2022. PMID:35880872 
  6. Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury. JAMA Netw Open. 2022;5(7):e2220969. PMID:35802371 
  7. Use of Magnetic Resonance Imaging in Neuroprognostication After Pediatric Cardiac Arrest: Survey of Current Practices. Pediatr Neurol. 2022;134:45-51. PMID:35835025 
  8. Association of chest compression pause duration prior to E-CPR cannulation with cardiac arrest survival outcomes. Resuscitation. 2022. PMID:35588971 
  9. Gut-brain axis in traumatic brain injury: impact on neuroinflammation. Neural Regen Res. 2022;17(5):1007-1008. PMID:34558522 
  10. Effect of Physiologic Point-of-Care Cardiopulmonary Resuscitation Training on Survival With Favorable Neurologic Outcome in Cardiac Arrest in Pediatric ICUs: A Randomized Clinical Trial. JAMA. 2022;327(10):934-945. PMID:35258533 
  11. Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury. JAMA Netw Open. 2022;5(3):e220891. PMCID:PMC8914575  PMID:35267036 
  12. Magnetic Resonance Imaging Adds Prognostic Value to EEG After Pediatric Cardiac Arrest. Resuscitation. 2022. PMID:35227820 
  13. Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury. Acta Neuropathol Commun. 2022;10(1):10. PMCID:PMC8796448  PMID:35090569 
  14. Risk factors and outcomes for recurrent paediatric in-hospital cardiac arrest: Retrospective multicenter cohort study. Resuscitation. 2021;169:60-66. PMID:34673152 
  15. Early Antibiotic Exposure in Severe Pediatric Traumatic Brain Injury. J Pediatric Infect Dis Soc. 2021. PMID:34555169 
  16. Trajectory of Long-Term Outcome in Severe Pediatric Diffuse Axonal Injury: An Exploratory Study. Front Neurol. 2021;12:704576. PMCID:PMC8477000  PMID:34594294 
  17. Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis. Acta Neuropathol Commun. 2021;9(1):40. PMCID:PMC7944629  PMID:33691793 
  18. Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research. Crit Care Explor. 2021;3(3):e0374. PMCID:PMC7994036  PMID:33786450 
  19. Preclinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases. J Neurotrauma. 2020. PMID:33297844 
  20. Personalising Outcomes after Child Cardiac Arrest (POCCA): design and recruitment challenges of a multicentre, observational study. BMJ Open. 2020;10(10):e039323. PMCID:PMC7592297  PMID:33109667 
  21. N-acetylcysteine reduces brain injury after delayed hypoxemia following traumatic brain injury. Exp Neurol. 2020;335:113507. PMID:33065076 
  22. Variability in chest compression rate calculations during pediatric cardiopulmonary resuscitation. Resuscitation. 2020;149:127-133. PMID:32088254 
  23. Neurological Prognostication in Children After Cardiac Arrest. Pediatr Neurol. 2020. PMID:32381279 
  24. Cardiac Arrest Outcomes in Children With Preexisting Neurobehavioral Impairment. Pediatr Crit Care Med. 2019;20(6):510-517. PMCID:PMC6548585  PMID:30807545 
  25. Presenting Characteristics Associated With Outcome in Children With Severe Traumatic Brain Injury: A Secondary Analysis From a Randomized, Controlled Trial of Therapeutic Hypothermia. Pediatr Crit Care Med. 2018;19(10):957-964. PMCID:PMC6170689  PMID:30067578 
  26. Neurologic outcomes in pediatric cardiac arrest survivors enrolled in the THAPCA trials. Neurology. 2018;91(2):e123-e131. PMID:29884735 
  27. Improving outcomes after pediatric cardiac arrest - the ICU-Resuscitation Project: study protocol for a randomized controlled trial. Trials. 2018;19(1):213. PMCID:PMC5883604  PMID:29615134 
  28. Characterization of Pediatric In-Hospital Cardiopulmonary Resuscitation Quality Metrics Across an International Resuscitation Collaborative. Pediatr Crit Care Med. 2018. PMID:29533355 
  29. Delayed Hypoxemia Following Traumatic Brain Injury Exacerbates Long-Term Behavioral Deficits. J Neurotrauma. 2017. PMID:29149808 
  30. Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med. 2017;376(4):318-329. PMCID:PMC5310766  PMID:28118559 
  31. Pediatric Out-of-Hospital Cardiac Arrest Characteristics and Their Association With Survival and Neurobehavioral Outcome. Pediatr Crit Care Med. 2016;17(12):e543-e550. PMCID:PMC5138073  PMID:27679965 
  32. Functional Outcome Trajectories After Out-of-Hospital Pediatric Cardiac Arrest. Crit Care Med. 2016;44(12):e1165-e1174. PMCID:PMC5129173  PMID:27509385 
  33. Blood Pressure- and Coronary Perfusion Pressure-Targeted Cardiopulmonary Resuscitation Improves 24-Hour Survival From Ventricular Fibrillation Cardiac Arrest. Crit Care Med. 2016;44(11):e1111-e1117. PMCID:PMC5069077  PMID:27414479 
  34. Targeted Temperature Management After Pediatric Cardiac Arrest Due To Drowning: Outcomes and Complications. Pediatr Crit Care Med. 2016;17(8):712-20. PMCID:PMC5123789  PMID:27362855 
  35. Early Electroencephalographic Findings Correlate With Neurologic Outcome in Children Following Cardiac Arrest. Pediatr Crit Care Med. 2016;17(7):667-76. PMID:27164188 
  36. Delayed Hypoxemia Following Traumatic Brain Injury Exacerbates White Matter Injury. J Neuropathol Exp Neurol. 2016. PMID:27288907 
  37. Comparing Apples and Oranges: Seizure Prophylaxis in Pediatric Traumatic Brain Injury. Pediatr Crit Care Med. 2016;17(2):173-4. PMID:26841031 
  38. Emergency Neurological Life Support: Resuscitation Following Cardiac Arrest. Neurocrit Care. 2015;23 Suppl 2:S119-28. PMID:26438463 
  39. Part 6: Pediatric Basic Life Support and Pediatric Advanced Life Support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (Reprint). Pediatrics. 2015;136 Suppl 2:S88-119. PMID:26471382 
  40. Part 6: Pediatric Basic Life Support and Pediatric Advanced Life Support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation. 2015;132(16 Suppl 1):S177-203. PMID:26472853 
  41. Part 6: Pediatric basic life support and pediatric advanced life support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Resuscitation. 2015;95:e147-68. PMID:26477423 
  42. Hepatic Mucormycosis Mimicking Veno-occlusive Disease: Report of a Case and Review of the Literature. Pediatr Dev Pathol. 2015. doi:10.2350/15-06-1661-CR.1  PMID:26366930 
  43. Decompressive craniectomy reduces white matter injury after controlled cortical impact in mice. J Neurotrauma. 2015;32(11):791-800. doi:10.1089/neu.2014.3564  PMID:25557588 
  44. Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med. 2015;372(20):1898-908. PMCID:PMC4470472  PMID:25913022 
  45. Differing effects when using phenylephrine and norepinephrine to augment cerebral blood flow after traumatic brain injury in the immature brain. J Neurotrauma. 2015;32(4):237-43. doi:10.1089/neu.2014.3468  PMCID:PMC4321769  PMID:25072522 
  46. The authors reply. Pediatr Crit Care Med. 2015;16(2):203. PMCID:PMC4339286  PMID:25647138 
  47. Patient-centric blood pressure-targeted cardiopulmonary resuscitation improves survival from cardiac arrest. Am J Respir Crit Care Med. 2014;190(11):1255-62. doi:10.1164/rccm.201407-1343OC  PMCID:PMC4315818  PMID:25321490 
  48. Greater fluctuations in serum sodium levels are associated with increased mortality in children with externalized ventriculostomy drains in a PICU. Pediatr Crit Care Med. 2014;15(9):846-55. doi:10.1097/PCC.0000000000000223  PMCID:PMC4221432  PMID:25137551 
  49. An ounce of prevention but less than a pound of cure: seizure prophylaxis after intracranial hemorrhage. Pediatr Crit Care Med. 2014;15(8):781-2. PMCID:PMC4185423  PMID:25280151 
  50. Risk factors associated with infections and need for permanent cerebrospinal fluid diversion in pediatric intensive care patients with externalized ventricular drains. Neurocrit Care. 2014;21(2):294-9. doi:10.1007/s12028-013-9946-7  PMCID:PMC4133323  PMID:24522759 
  51. Hemodynamic directed CPR improves cerebral perfusion pressure and brain tissue oxygenation. Resuscitation. 2014;85(9):1298-303. doi:10.1016/j.resuscitation.2014.05.040  PMCID:PMC4138228  PMID:24945902 
  52. Endovascular perforation subarachnoid hemorrhage fails to cause Morris water maze deficits in the mouse. J Cereb Blood Flow Metab. 2014;34(9). doi:10.1038/jcbfm.2014.108  PMCID:PMC4158664  PMID:24938403 
  53. Hemodynamic-directed cardiopulmonary resuscitation during in-hospital cardiac arrest. Resuscitation. 2014;85(8):983-6. doi:10.1016/j.resuscitation.2014.04.015  PMCID:PMC4087068  PMID:24783998 
  54. High frequency oscillation and airway pressure release ventilation in pediatric respiratory failure. Pediatr Pulmonol. 2014;49(7):707-15. doi:10.1002/ppul.22853  PMCID:PMC4092114  PMID:23853049 
  55. Improved oxygenation 24 hours after transition to airway pressure release ventilation or high-frequency oscillatory ventilation accurately discriminates survival in immunocompromised pediatric patients with acute respiratory distress syndrome*. Pediatr Crit Care Med. 2014;15(4):e147-56. doi:10.1097/PCC.0000000000000069  PMCID:PMC4114308  PMID:24413319 
  56. Hemodynamic directed cardiopulmonary resuscitation improves short-term survival from ventricular fibrillation cardiac arrest. Crit Care Med. 2013;41(12):2698-704. doi:10.1097/CCM.0b013e318298ad6b  PMCID:PMC3812371  PMID:23887237 
  57. Improved behavior, motor, and cognition assessments in neonatal piglets. J Neurotrauma. 2013;30(20):1770-9. doi:10.1089/neu.2013.2913  PMCID:PMC3796335  PMID:23758416 
  58. Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury. Crit Care Med. 2013;41(10):2379-87. doi:10.1097/CCM.0b013e318292316c  PMCID:PMC3783553  PMID:23896831 
  59. Nonconvulsive electrographic seizures are common in children with abusive head trauma*. Pediatr Crit Care Med. 2013;14(7):709-15. doi:10.1097/PCC.0b013e3182917b83  PMCID:PMC4082326  PMID:23842589 
  60. Hemodynamic directed CPR improves short-term survival from asphyxia-associated cardiac arrest. Resuscitation. 2013;84(5):696-701. doi:10.1016/j.resuscitation.2012.10.023  PMCID:PMC3612383  PMID:23142199 
  61. Behavioral deficits and axonal injury persistence after rotational head injury are direction dependent. J Neurotrauma. 2013;30(7):538-45. doi:10.1089/neu.2012.2594  PMCID:PMC3636580  PMID:23216054 
  62. The anesthetic effects on vasopressor modulation of cerebral blood flow in an immature swine model. Anesth Analg. 2013;116(4):838-44. doi:10.1213/ANE.0b013e3182860fe7  PMCID:PMC3606687  PMID:23460561 
  63. Electrographic status epilepticus is associated with mortality and worse short-term outcome in critically ill children. Crit Care Med. 2013;41(1):215-23. doi:10.1097/CCM.0b013e3182668035  PMCID:PMC3531581  PMID:23164815 
  64. New tricks for an old dog: multimodal neuromonitoring for diabetic ketoacidosis-associated cerebral edema*. Pediatr Crit Care Med. 2012;13(6):702-3. PMID:23128596 
  65. Early cerebral perfusion pressure augmentation with phenylephrine after traumatic brain injury may be neuroprotective in a pediatric swine model. Crit Care Med. 2012;40(8):2400-6. doi:10.1097/CCM.0b013e31825333e6  PMCID:PMC3400930  PMID:22809910 
  66. Coagulopathy after pediatric traumatic brain injury: association or causality? Pediatr Crit Care Med. 2012;13(4):491-2. PMID:22766549 
  67. Premedication with meloxicam exacerbates intracranial haemorrhage in an immature swine model of non-impact inertial head injury. Lab Anim. 2012;46(2):164-6. doi:10.1258/la.2011.011084  PMCID:PMC3971837  PMID:22238292 
  68. Advanced neuromonitoring and imaging in pediatric traumatic brain injury. Crit Care Res Pract. 2012;2012:361310. PMCID:PMC3363371  PMID:22675618 
  69. Bi-caval dual lumen venovenous extracorporeal membrane oxygenation and high-frequency percussive ventilatory support for postintubation tracheal injury and acute respiratory distress syndrome. J Pediatr Surg. 2011;46(12):e11-5. doi:10.1016/j.jpedsurg.2011.09.048  PMID:22152899 
  70. Neurocritical care monitoring correlates with neuropathology in a swine model of pediatric traumatic brain injury. Neurosurgery. 2011;69(5):1139-47; discussion 1147. doi:10.1227/NEU.0b013e3182284aa1  PMCID:PMC3188667  PMID:21670716 
  71. Physiological and histopathological responses following closed rotational head injury depend on direction of head motion. Exp Neurol. 2011;227(1):79-88. doi:10.1016/j.expneurol.2010.09.015  PMCID:PMC3021173  PMID:20875409 
  72. Is pediatric neurointensive care a legitimate programmatic advancement to benefit our patients and our trainees, or others? Pediatr Crit Care Med. 2010;11(6):758-60. PMID:21057270 
  73. Sedation and analgesia in children with developmental disabilities and neurologic disorders. Int J Pediatr. 2010;2010. PMCID:PMC2913544  PMID:20706547 
  74. Folic acid enhances early functional recovery in a piglet model of pediatric head injury. Dev Neurosci. 2010;32(5-6):466-79. doi:10.1159/000322448  PMCID:PMC3073761  PMID:21212637 
  75. Repeated traumatic brain injury affects composite cognitive function in piglets. J Neurotrauma. 2009;26(7):1111-21. doi:10.1089/neu.2008.0845  PMCID:PMC2848948  PMID:19275468 
  76. Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. J Biomed Opt. 2009;14(3):034015. doi:10.1117/1.3146814  PMCID:PMC3169814  PMID:19566308 
  77. Neurobehavioral functional deficits following closed head injury in the neonatal pig. Exp Neurol. 2007;204(1):234-43. doi:10.1016/j.expneurol.2006.10.010  PMCID:PMC1892165  PMID:17174304 
  78. Use of recombinant factor VIIa for refractory hemorrhage during extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2005;6(3):348-51. doi:10.1097/01.PCC.0000161623.51275.0F  PMID:15857537 
Last updated: 10/20/2022
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