Department of Pediatrics

Clinical Interests

I am board certified in pediatrics and pediatric gastroenterology, and I have >15 years of experience caring for patients with a wide range of pediatric GI, liver and pancreatic diseases.

Education

• BS, University of Illinois, 1987
• MD, Washington University School of Medicine, 1994
• PhD, Washington University School of Medicine , 1994

Training

• Internship, St. Louis Children's Hospital, 1994 - 1995
• Residency, St. Louis Children's Hospital, 1995 - 1997
• Fellowship, Washington University School of Medicine, 1997 - 2000

Licensure and Board Certification

• 1997 - PresMO
• 1997American Board of Pediatrics, General Pediatrics
• 2001American Board of Pediatrics, Sub-board of Pediatric Gastroenterology
• 2004 - PresAmerican Board of Pediatrics, General Pediatrics, Recertification
• 2008 - PresAmerican Board of Pediatrics, Sub-board of Pediatric Gastroenterology, Recertification

Honors and Awards

• Phi Beta Kappa, University of Illinois Chapter, 1987
• Summa Cum Laude, University of Illinois, 1987
• American Federation for Clinical Research, Medical Student Award, Washington University Medical School, 1992
• Spencer T. and Ann W. Olin Foundation Medical Scientist Predoctoral, Fellowship, Washington University Medical School, 1992
• American College of Physicians Award for Excellence in Physical Diagnosis, Washington University Medical School, 1993
• Alpha Omega Alpha, Washington University Medical School Chapter, 1994
• The Dr. Phillip Needleman Pharmacology Award, Washington University Medical School, 1994
• The George F. Gill Prize in Pediatrics, Washington University Medical School, 1994
• Scholar of the Child Health Research Center for Excellence in Developmental Biology at Washington University Medical School, 2000 - 2003
• NASPGHAN Young Faculty Investigator Award, 2003
• Research Excellence in GI and Liver (REGAL) Award, 2003
• Best Doctors in America, 2007 - Pres
• WUMS Distinguished Investigator Award, 2008
• NASPGHAN Foundation Mid-Level Career Development Award, 2015

Recent Publications view all (54)

Publication Co-Authors

Dennis J. Dietzen, Ph.D.

Stephen C. Pak, Ph.D.

Sakil S Kulkarni, MD

David B. Wilson, M.D., Ph.D.

David Perlmutter, M.D.

Gary A. Silverman, M.D., Ph.D.

Paul W. Hruz, M.D., Ph.D.

Mark E. Lowe, M.D., Ph.D.

Tunda Hidvegi, Ph.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with David A. Rudnick, M.D., Ph.D.

1. Rudnick DA, Huang J, Hidvegi T, Chu AS, Hale P, Munanairi A, Dietzen DJ, Cliften PF, Tycksen E, Lutkewitte AJ, Finck BN, Pak SC, Silverman GA, Perlmutter DH. Regulation of PGC1α downstream of the insulin signaling pathway plays a role in the hepatic proteotoxicity of mutant α1-antitrypsin deficiency variant Z. Gastroenterology. 2022. PMID:35301011 
2. Pihlajoki M, Soini T, Cochran RB, Liljeström E, Huang J, Rudnick DA, Dietzen DJ, Kyrönlahti A, Pakarinen MP, Heikinheimo M, Wilson DB. GATA6 modulates the ductular reaction to bile duct ligation. Hepatol Int. 2021;15(1):166-178. PMID:33486744 
3. Kulkarni S, Huang J, Tycksen E, Cliften PF, Rudnick DA. Diet Modifies Pioglitazone's Influence on Hepatic PPARγ-Regulated Mitochondrial Gene Expression. PPAR Res. 2020;2020:3817573. PMCID:PMC7501566  PMID:32963510 
4. Wilson DB, Rudnick DA. Invasive Ductular Reaction: Form and Function. Am J Pathol. 2019;189(8):1501-1504. PMID:31202722 
5. Squires JE, Rudnick DA, Hardison RM, Horslen S, Ng VL, Alonso EM, Belle SH, Squires RH. Liver Transplant Listing in Pediatric Acute Liver Failure: Practices and Participant Characteristics. Hepatology. 2018;68(6):2338-2347. PMCID:PMC6275095  PMID:30070372 
6. Soini T, Pihlajoki M, Andersson N, Lohi J, Huppert KA, Rudnick DA, Huppert SS, Wilson DB, Pakarinen MP, Heikinheimo M.. Transcription factor GATA6: a novel marker and putative inducer of ductal metaplasia in biliary atresia. Am J Physiol Gastrointest Liver Physiol. 2018;314(5):G547-G558. doi:doi: 10.1152/ajpgi.00362.2017.  PMID:29388792 
7. Sorensen LG, Neighbors K, Hardison RM, Loomes KM, Varni JW, Ng VL, Squires RH, Alonso EM, Pediatric Acute Liver Failure Study Group.. Health Related Quality of Life and Neurocognitive Outcomes in the First Year after Pediatric Acute Liver Failure. J Pediatr. 2018;196:129-138.e3. PMCID:PMC5933443  PMID:29551316 
8. Kulkarni S, Rudnick DA. Induced Pluripotent Stem Cell-Derived Hepatocytes and Precision Medicine in Human Liver Disease. J Pediatr Gastroenterol Nutr. 2018;66(5):716-719. PMID:29509632 
9. Narkewicz MR, Horslen S, Hardison RM, Shneider BL, Rodriguez-Baez N, Alonso EM, Ng VL, Leonis MA, Loomes KM, Rudnick DA, Rosenthal P, Romero R, Subbarao GC, Li R, Belle SH, Squires RH; Pediatric Acute Liver Failure Study Group.. A Learning Collaborative Approach Increases Specificity of Diagnosis of Acute Liver Failure in Pediatric Patients. Clin Gastroenterol Hepatol. 2018;Epub ahead of print](doi: 10.1016/j.cgh.2018.04.050.):pii: S1542-3565(18)30455-5.. PMID:29723692 
10. Rudnick DA. Antifibrotic therapies in liver disease: Ready for primetime? Clin Liver Dis (Hoboken). 2017;9(6):138-140. PMCID:PMC6467161  PMID:30992978 
11. Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH, Pediatric Acute Liver Failure Study Group. Prevalence and Significance of Autoantibodies in Children With Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2017;64(2):210-217. PMCID:PMC5250572  PMID:27496798 
12. Ng VL, Li R, Loomes KM, Leonis MA, Rudnick DA, Belle SH, Squires RH, Pediatric Acute Liver Failure Study Group (PALFSG). Outcomes of Children With and Without Hepatic Encephalopathy From the Pediatric Acute Liver Failure Study Group. J Pediatr Gastroenterol Nutr. 2016;63(3):357-64. PMCID:PMC4992416  PMID:27367788 
13. Li R, Belle SH, Horslen S, Chen LW, Zhang S, Squires RH, Pediatric Acute Liver Failure Study Group.. Clinical Course among Cases of Acute Liver Failure of Indeterminate Diagnosis. J Pediatr. 2016;171:163-70.e1-3. PMCID:PMC4808594  PMID:26831743 
14. Huang J, Schriefer AE, Cliften PF, Dietzen D, Kulkarni S, Sing S, Monga SP, Rudnick DA. Postponing the Hypoglycemic Response to Partial Hepatectomy Delays Mouse Liver Regeneration. Am J Pathol. 2016;186(3):587-99. doi:10.1016/j.ajpath.2015.10.027  PMID:26772417 
15. Knipstein B, Huang J, Barr E, Sossenheimer P, Dietzen D, Egner PA, Groopman JD, Rudnick DA. Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance. Pediatr Res. 2015;78(2):120-127. doi:10.1038/pr.2015.84  PMCID:PMC4506701  PMID:25938735 
16. Teckman JH, Rosenthal P, Abel R, Bass LM, Michail S, Murray KF, Rudnick DA, Thomas DW, Spino C, Arnon R, Hertel PM, Heubi J, Kamath BM, Karnsakul W, Loomes KM, Magee JC, Molleston JP, Romero R, Shneider BL, Sherker AH, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension. J Pediatr Gastroenterol Nutr. 2015;61(1):94-101. doi:10.1097/MPG.0000000000000753  PMID:25651489 
17. Schwarz KB, Dell Olio D, Lobritto SJ, Lopez MJ, Rodriguez-Baez N, Yazigi NA, Belle SH, Zhang S, Squires RH, Pediatric Acute Liver Failure Study Group.. Analysis of viral testing in nonacetaminophen pediatric acute liver failure. J Pediatr Gastroenterol Nutr. 2014;59(5):616-23. PMCID:PMC4305349  PMID:25340974 
18. Kong B, Huang J, Zhu Y, Li G, Williams J, Shen S, Aleksunes LM, Richardson JR, Apte U, Rudnick DA, Guo GL. Fibroblast growth factor 15 deficiency impairs liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol. 2014;306(10):G893-902. doi:10.1152/ajpgi.00337.2013  PMCID:PMC4024724  PMID:24699334 
19. Huang J, Rudnick DA. Elucidating the metabolic regulation of liver regeneration. Am J Pathol. 2014;184(2):309-21. PMCID:PMC3906487  PMID:24139945 
20. Huang J, Schriefer AE, Yang W, Cliften PF, Rudnick DA. Identification of an epigenetic signature of early mouse liver regeneration that is disrupted by Zn-HDAC inhibition. Epigenetics. 2014;9(11):1521-31. doi:10.4161/15592294.2014.983371  PMID:25482284 
21. Kassel R, Sprietsma L, Rudnick DA. Pregnancy in an NTBC-treated patient with hereditary tyrosinemia type I. J Pediatr Gastroenterol Nutr. 2013. doi:10.1097/MPG.0b013e3182a27463  PMID:23838819 
22. Huang J, Barr E, Rudnick DA. Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration. Hepatology. 2013;57(5):1742-51. doi:10.1002/hep.26206  PMID:23258575 
23. Squires RH, Dhawan A, Alonso E, Narkewicz MR, Shneider BL, Rodriguez-Baez N, Olio DD, Karpen S, Bucuvalas J, Lobritto S, Rand E, Rosenthal P, Horslen S, Ng V, Subbarao G, Kerkar N, Rudnick D, Lopez MJ, Schwarz K, Romero R, Elisofon S, Doo E, Robuck PR, Lawlor S, Belle SH, Pediatric Acute Liver Failure Study Group. Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial. Hepatology. 2013;57(4):1542-9. doi:10.1002/hep.26001  PMCID:PMC3509266  PMID:22886633 
24. Leonis MA, Alonso EM, Im K, Belle SH, Squires RH, Pediatric Acute Liver Failure Study Group.. Chronic acetaminophen exposure in pediatric acute liver failure. Pediatrics. 2013;131(3):e740-6. PMCID:PMC3581836  PMID:23439908 
25. Azhar N, Ziraldo C, Barclay D, Rudnick DA, Squires RH, Vodovotz Y, Pediatric Acute Liver Failure Study Group. Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. PLoS One. 2013;8(11):e78202. doi:10.1371/journal.pone.0078202  PMCID:PMC3823926  PMID:24244295 
26. Gazit V, Huang J, Weymann A, Rudnick DA. Analysis of the role of hepatic PPARγ expression during mouse liver regeneration. Hepatology. 2012;56(4):1489-98. doi:10.1002/hep.25880  PMCID:PMC3465497  PMID:22707117 
27. Huang J, Glauber M, Qiu Z, Gazit V, Dietzen DJ, Rudnick DA. The influence of skeletal muscle on the regulation of liver:body mass and liver regeneration. Am J Pathol. 2012;180(2):575-82. doi:10.1016/j.ajpath.2011.10.032  PMCID:PMC3349872  PMID:22155110 
28. Rudnick DA, Davidson NO. Functional Relationships between Lipid Metabolism and Liver Regeneration. Int J Hepatol. 2012;2012:549241. PMCID:PMC3272806  PMID:22319652 
29. Gazit V, Weymann A, Hartman E, Finck BN, Hruz PW, Tzekov A, Rudnick DA. Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice. Hepatology. 2010;52(6):2109-17. doi:10.1002/hep.23920  PMCID:PMC2991544  PMID:20967828 
30. Kaushal S, Annamali M, Blomenkamp K, Rudnick D, Halloran D, Brunt EM, Teckman JH . Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model Exp Biol Med (Maywood). 2010;235(6):700-709. PMID:20511674 
31. Marcus NY, Brunt EM, Blomenkamp K, Ali F, Rudnick DA, Ahmad M, Teckman JH. Characteristics of hepatocellular carcinoma in a murine model of alpha-1-antitrypsin deficiency. Hepatol Res. 2010;40(6):641-53. doi:10.1111/j.1872-034X.2010.00663.x  PMCID:PMC2928671  PMID:20618460 
32. Ge J, Rudnick DA, He J, Crimmins DL, Ladenson JH, Bessler M, Mason PJ. Dyskerin ablation in mouse liver inhibits rRNA processing and cell division. Mol Cell Biol. 2010;30(2):413-22. doi:10.1128/MCB.01128-09  PMCID:PMC2798470  PMID:19917719 
33. Qiu Z, Longshore SW, Warner BW, Rudnick DA. Murine functional liver mass is reduced following partial small bowel resection. J Gastrointest Surg. 2009;13(12):2176-82. doi:10.1007/s11605-009-1043-z  PMCID:PMC3034449  PMID:19774425 
34. Weymann A, Hartman E, Gazit V, Wang C, Glauber M, Turmelle Y, Rudnick DA.. p21 is required for dextrose-mediated inhibition of mouse liver regeneration Hepatology. 2009;50(1):207-215. PMCID:PMC2705473   PMID:19441104 
35. Rudnick DA, Dietzen DJ, Turmelle YP, Shepherd R, Zhang S, Belle SH, Squires R, Pediatric Acute Liver Failure Study Group. Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure. Pediatr Transplant. 2009;13(2):223-30. doi:10.1111/j.1399-3046.2008.00998.x  PMCID:PMC2659723  PMID:18643912 
36. Clark A, Weymann A, Hartman E, Turmelle Y, Carroll M, Thurman JM, Holers VM, Hourcade DE, Rudnick DA. Evidence for non-traditional activation of complement factor C3 during murine liver regeneration. Mol Immunol. 2008;45(11):3125-32. doi:10.1016/j.molimm.2008.03.008  PMCID:PMC2600895  PMID:18452991 
37. Turmelle YP, Shikapwashya O, Tu S, Hruz PW, Yan Q, Rudnick DA. Rosiglitazone inhibits mouse liver regeneration. FASEB J. 2006;20(14):2609-11. doi:10.1096/fj.06-6511fje  PMID:17077279 
38. Rudnick DA, Shikapwashya O, Blomenkamp K, Teckman JH. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency. Hepatology. 2006;44(4):976-82. doi:10.1002/hep.21326  PMID:17006946 
39. Shteyer E, Liao Y, Muglia LJ, Hruz PW, Rudnick DA. Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. Hepatology. 2004;40(6):1322-32. doi:10.1002/hep.20462  PMID:15565660 
40. Liao Y, Shikapwashya ON, Shteyer E, Dieckgraefe BK, Hruz PW, Rudnick DA. Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice. J Biol Chem. 2004;279(41):43107-16. doi:10.1074/jbc.M407969200  PMID:15265859 
41. Rudnick DA, Liao Y, An JK, Muglia LJ, Perlmutter DH, Teckman JH. Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency. Hepatology. 2004;39(4):1048-55. doi:10.1002/hep.20118  PMID:15057909 
42. Imamura T, Asada M, Vogt SK, Rudnick DA, Lowe ME, Muglia LJ. Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1. J Biol Chem. 2002;277(52):50725-33. doi:10.1074/jbc.M204159200  PMID:12401800 
43. Rudnick DA, Perlmutter DH, Muglia LJ. Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration. Proc Natl Acad Sci U S A. 2001;98(15):8885-90. doi:10.1073/pnas.151217998  PMCID:PMC37530  PMID:11447268 
44. Rudnick DA, Rocque WJ, McWherter CA, Toth MV, Jackson-Machelski E, Gordon JI. Use of photoactivatable peptide substrates of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) to characterize a myristoyl-CoA-Nmt1p-peptide ternary complex and to provide evidence for an ordered reaction mechanism. Proc Natl Acad Sci U S A. 1993;90(3):1087-91. PMCID:PMC45816  PMID:8430078 
45. Johnson DR, Duronio RJ, Langner CA, Rudnick DA, Gordon JI. Genetic and biochemical studies of a mutant Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase, nmt72pLeu99-->Pro, that produces temperature-sensitive myristic acid auxotrophy. J Biol Chem. 1993;268(1):483-94. PMID:8416952 
46. Rudnick DA, Johnson RL, Gordon JI. Studies of the catalytic activities and substrate specificities of Saccharomyces cerevisiae myristoyl-coenzyme A: protein N-myristoyltransferase deletion mutants and human/yeast Nmt chimeras in Escherichia coli and S. cerevisiae. J Biol Chem. 1992;267(33):23852-61. PMID:1429724 
47. Rudnick DA, Lu T, Jackson-Machelski E, Hernandez JC, Li Q, Gokel GW, Gordon JI. Analogs of palmitoyl-CoA that are substrates for myristoyl-CoA:protein N-myristoyltransferase. Proc Natl Acad Sci U S A. 1992;89(21):10507-11. PMCID:PMC50368  PMID:1438240 
48. Devadas B, Lu T, Katoh A, Kishore NS, Wade AC, Mehta PP, Rudnick DA, Bryant ML, Adams SP, Li Q. Substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Analysis of fatty acid analogs containing carbonyl groups, nitrogen heteroatoms, and nitrogen heterocycles in an in vitro enzyme assay and subsequent identification of inhibitors of human immunodeficiency virus I replication. J Biol Chem. 1992;267(11):7224-39. PMID:1559967 
49. Duronio RJ, Rudnick DA, Adams SP, Towler DA, Gordon JI. Analyzing the substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase by co-expressing it with mammalian G protein alpha subunits in Escherichia coli. J Biol Chem. 1991;266(16):10498-504. PMID:1903791 
50. Duronio RJ, Rudnick DA, Johnson RL, Johnson DR, Gordon JI. Myristic acid auxotrophy caused by mutation of S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase. J Cell Biol. 1991;113(6):1313-30. PMCID:PMC2289034  PMID:2045414 
51. Rudnick DA, McWherter CA, Rocque WJ, Lennon PJ, Getman DP, Gordon JI. Kinetic and structural evidence for a sequential ordered Bi Bi mechanism of catalysis by Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. J Biol Chem. 1991;266(15):9732-9. PMID:2033063 
52. Gordon JI, Duronio RJ, Rudnick DA, Adams SP, Gokel GW. Protein N-myristoylation. J Biol Chem. 1991;266(14):8647-50. PMID:2026581 
53. Kishore NS, Lu TB, Knoll LJ, Katoh A, Rudnick DA, Mehta PP, Devadas B, Huhn M, Atwood JL, Adams SP. The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Analysis of myristic acid analogs containing oxygen, sulfur, double bonds, triple bonds, and/or an aromatic residue. J Biol Chem. 1991;266(14):8835-55. PMID:2026598 
54. Rudnick DA, McWherter CA, Adams SP, Ropson IJ, Duronio RJ, Gordon JI. Structural and functional studies of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase produced in Escherichia coli. Evidence for an acyl-enzyme intermediate. J Biol Chem. 1990;265(22):13370-8. PMID:2198291