Department of Pediatrics

Clinical Interests

Pediatric inflammatory bowel disease and general pediatric gastrointestinal illness

Education

• BS, Highest Distinction and Highest Honors, University of North Carolina at Chapel Hill, 1998
• MD, Thesis Honors, University of Washington, 2003

Training

• Pediatric Residency, Univeristy of North Carolina at Chapel Hill/NC Children's Hospital, 2003 - 2006
• Pediatric Gastroenterology Fellowship, Cincinnati Children's Hospital Medical Center, 2006 - 2009
• Advanced Improvement Methods Workshop, Cincinnati Children's Hospital Medical Center, 2014 - 2015
• Pediatric Leadership Development Program, Washington University School of Medicine, 2016 - 2016
• Academic Medical Leadership Program for Physicians & Scientists, Washington University School of Medicine, Washington University Olin Business School, & BJC Healthcare, 2018 - 2018
• Educational Skills Program, Washington University School of Medicine, 2018 - 2019

Licensure and Board Certification

• 2003 - 2006NC, NC Training License
• 2006 - 2009OH, Ohio Training Certificate
• 2006 - PresAmerican Board of Pediatrics; General Pediatrics
• 2009 - 2012OH, Ohio Medical License
• 2009 - PresAmerican Board of Pediatrics; Pediatric Gastroenterology
• 2011 - PresMO, Missouri Medical License
• 2016 - 2019AR, Arkansas Medical License
• 2020 - PresIL, Illinois Medical License

Honors and Awards

• David L Stern Award; Department of Chemistry; University of North Carolina at Chapel Hill, 1997
• Phi Beta Kappa; University of North Carolina at Chapel Hill, 1997
• Highest Distinction Graduate; University of North Carolina at Chapel Hill, 1998
• Highest Honor's Thesis in Chemistry; University of North Carolina at Chapel Hill, 1998
• Venable Medal; Department of Chemistry; University of North Carolina at Chapel Hill, 1998
• Medical Thesis Honors; University of Washington School of Medicine, 2002
• Fellowship to Faculty Transition Award; Foundation of the American Gastroenterological Association, 2009
• Pediatric Loan Repayment Award; National Institutes of Health, 2009
• Procter Scholar Award; Cincinnati Children's Hospital Medical Center, 2009
• Poster of Distinction, Digestive Disease Week, 2011

Recent Publications view all (24)

Publication Co-Authors

Phillip I. Tarr, M.D.

Anthony R. French, MD, PhD

Sakil S Kulkarni, MD

Kim H. H. Liss, M.D.

Fahd Ahmad, M.D., M.S.C.I.

Kimberly S. Quayle, M.D.

Kevin Baszis, M.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Charles Samson, M.D.

1. Cohen ME, Deepak P, Khanna G, Samson CM. Evaluation of Nonalcoholic Fatty Liver Disease in Pediatric Patients With Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2021;72(4):574-578. PMID:33346578 
2. Gupta N, Liu C, King E, Sylvester F, Lee D, Boyle B, Trauernicht A, Chen S, Colletti R, ImproveCareNow Network .. Continued Statural Growth in Older Adolescents and Young Adults With Crohn's Disease and Ulcerative Colitis Beyond the Time of Expected Growth Plate Closure. Inflamm Bowel Dis. 2020;26(12):1880-1889. PMID:31968095 
3. Khare R, Kappelman M, Samson C, Pyrzanowski J, Darwar RA, Forrest CB, Bailey CC, Margolis P, Dempsey A, and the PEDSnet Computable Phenotype Working Group . Development and evaluation of an EHR‐based computable phenotype for identification of pediatric Crohn's disease patients in a National Pediatric Learning Health System. Learning Health Systems. 2020;4:e10243. doi:https://doi.org/10.1002/lrh2.10243  
4. Pratt J, Jeffers D, King EC, Kappelman MD, Collins J, Margolis P, Baron H, Bass JA, Bassett MD, Beasley GL, Benkov KJ, Bornstein JA, Cabrera JM, Crandall W, Dancel LD, Garin-Laflam MP, Grunow JE, Hirsch BZ, Hoffenberg E, Israel E, Jester TW, Kiparissi F, Lakhole A, Lapsia SP, Minar P, Navarro FA, Neef H, Park KT, Pashankar DS, Patel AS, Pineiro VM, Samson CM, Sandberg KC, Steiner SJ, Strople JA, Sudel B, Sullivan JS, Suskind DL, Uppal V, Wali PD. Implementing a Novel Quality Improvement-Based Approach to Data Quality Monitoring and Enhancement in a Multipurpose Clinical Registry. EGEMS (Wash DC). 2019;7(1):51. PMCID:PMC6777196  PMID:31646151 
5. Puffenbarger MS, Ahmad FA, Argent M, Gu H, Samson C, Quayle KS, Saito JM.. Reduction of Computed Tomography Use for Pediatric Closed Head Injury Evaluation at a Nonpediatric Community Emergency Department Acad Emerg Med. 2018;e pub. PMID:30428150 
6. Walsh KE, Marsolo KA, Davis C, Todd T, Martineau B, Arbaugh C, Verly F, Samson C, Margolis P. Accuracy of the medication list in the electronic health record-implications for care, research, and improvement. J Am Med Inform Assoc. 2018;25(7):909-912. PMID:29771350 
7. Benkov KJ, Russell GH, Samson CM, Steiner SJ, King EC, Pratt J, Eichner SF, Colletti RB, and the ImproveCareNow Network. The Use of Concomitant Immunomodulators with Adalimumab Therapy in Pediatric Crohn's Disease J Clin Cell Immunol. 2018;9(1):e pub. 
8. El-Matary W, Dykes DMH, Bauman L, Elkadri A, Carroll MW, Izaguirre MR, deBruyn J, Samson CM, Crim AM, Ali S, Grossman A. Rapid Infliximab Infusion in Children with Inflammatory Bowel Disease: A Multicenter North American Experience. Inflamm Bowel Dis. 2017;23(12):2104-2108. PMID:29140940 
9. Fotis L, Shaikh N, Baszis KW, Samson CM, Lev-Tzion R, French AR, Tarr PI. Serologic Evidence of Gut-driven Systemic Inflammation in Juvenile Idiopathic Arthritis J Rheum. 2017;44(11):1624-31. PMID:28916545 
10. Kulkarni S, Liss K, Samson CM. Application of Conjoint Analysis to Improve Reliability of Dietician Consultation in Pediatric Celiac Disease. Pediatr Qual Saf. 2017;2(4):e029. PMCID:PMC6132477  PMID:30229166 
11. Samson CM, Mager D, Frazee S, Yu F. Remission in Pediatric Inflammatory Bowel Disease Correlates With Prescription Refill Adherence Rates. J Pediatr Gastroenterol Nutr. 2017;64(4):575-579. PMID:27299424 
12. Samson CM, Morgan P, Williams E, Beck L, Addie-Carson R, McIntire S, Booth A, Mendez E, Luzader C, Tomer G, Saeed S, Donovan E, Bucuvalas J, Denson LA. Improved outcomes with quality improvement interventions in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2012;55(6):679-88. PMID:22699837 
13. Otley A, LeLeiko N, Langton C, Lerer T, Mack D, Evans J, Pfefferkorn M, Carvalho R, Rosh J, Griffiths A, Oliva-Hemker M, Kay M, Bousvaros A, Stephens M, Samson C, Grossman A, Keljo D, Markowitz J, Hyams J, Pediatric IBD Collaborative Research Group.. Budesonide use in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2012;55(2):200-4. PMID:22258289 
14. Crandall WV, Margolis PA, Kappelman MD, King EC, Pratt JM, Boyle BM, Duffy LF, Grunow JE, Kim SC, Leibowitz I, Schoen BT, Colletti RB, ImproveCareNow Collaborative.. Improved outcomes in a quality improvement collaborative for pediatric inflammatory bowel disease. Pediatrics. 2012;129(4):e1030-41. PMCID:PMC3313634  PMID:22412030 
15. Samson CM, Jurickova I, Molden E, Schreiner W, Colliver J, Bonkowski E, Han X, Trapnell BC, Denson LA. Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice. Inflamm Bowel Dis. 2011;17(12):2443-55. PMCID:PMC3111853  PMID:21381154 
16. Hyams JS, Lerer T, Mack D, Bousvaros A, Griffiths A, Rosh J, Otley A, Evans J, Stephens M, Kay M, Keljo D, Pfefferkorn M, Saeed S, Crandall W, Michail S, Kappelman MD, Grossman A, Samson C, Sudel B, Oliva-Hemker M, Leleiko N, Markowitz J, Pediatric Infl ammatory Bowel Disease Collaborative Research Group Registry.. Outcome following thiopurine use in children with ulcerative colitis: a prospective multicenter registry study. Am J Gastroenterol. 2011;106(5):981-7. PMID:21224840 
17. Dotson JL, Crandall W, Mousa H, Honegger JR, Denson L, Samson C, Cunningham D, Balint J, Dienhart M, Jaggi P, Carvalho R. Presentation and outcome of histoplasmosis in pediatric inflammatory bowel disease patients treated with antitumor necrosis factor alpha therapy: a case series. Inflamm Bowel Dis. 2011;17(1):56-61. PMID:20645322 
18. Han X, Gilbert S, Groschwitz K, Hogan S, Jurickova I, Trapnell B, Samson C, Gully J. Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury. Gut. 2010;59(8):1066-78. PMCID:PMC4296557  PMID:20584783 
19. Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009;136(4):1261-71, e1-3. PMID:19230854 
20. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ, Brenner DA, Rippe RA, Behrns KE. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol. 2004;40(6):942-51. PMID:15158334 
21. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA, Brenner DA, Behrns KE. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Surgery. 2004;135(6):619-28. PMID:15179368 
22. Lange PA, Samson CM, Bird MA, Hayden MA, Behrns KE. Cirrhotic hepatocytes exhibit decreased TGFbeta growth inhibition associated with downregulated Smad protein expression. Biochem Biophys Res Commun. 2004;313(3):546-51. PMID:14697224 
23. Bird MA, Black D, Lange PA, Samson CM, Hayden M, Behrns KE. NFkappaB inhibition decreases hepatocyte proliferation but does not alter apoptosis in obstructive jaundice. J Surg Res. 2003;114(2):110-7. PMID:14559434 
24. Samson CM, Schrum LW, Bird MA, Lange PA, Brenner DA, Rippe RA, Behrns KE. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Surgery. 2002;132(3):441-9. PMID:12324757