Research in mice offers clues for vaccinating against deadly bacteria (Links to an external site)

A mouse study at Washington University School of Medicine in St. Louis points to data that could be key to developing an effective vaccine for the bacterium Klebsiella pneumoniae. The bug is often resistant to antibiotics, making it difficult to treat in some.

In the U.S., the bacterium Klebsiella pneumoniae is a common cause of urinary tract infection, bloodstream infection and pneumonia. While infections with the bacterium can be easily treated in some, Klebsiella has a dangerous flip side: It also is frequently resistant to antibiotics, making it extraordinarily difficult to treat in others. About half of people infected with a hypervirulent, […]

Bloodstream infections in preemies may originate from their gut microbiomes (Links to an external site)

A new study from Washington University School of Medicine in St. Louis suggests that some dangerous bloodstream infections in premature infants may be caused by strains of bacteria already lurking in their gut microbiomes.

Dangerous bacterial bloodstream infections in preemies may originate from the infants’ gut microbiomes, according to researchers at Washington University School of Medicine in St. Louis. Such infections are of substantial concern, as about half of infants who are extremely preterm or have very low birth weights experience at least one episode of the life-threatening infection […]

Researchers elected to American Society for Clinical Investigation (Links to an external site)

Eight researchers at Washington University School of Medicine in St. Louis have been elected members of the newest class of the American Society for Clinical Investigation.

Eight physician-scientists at Washington University School of Medicine in St. Louis have been elected members of the newest class of the American Society for Clinical Investigation. They are being recognized for their original, creative and independent investigations in the clinical or allied sciences of medicine. The new members, who will be inducted April 21, are Megan […]

Study: St. Louis Children’s Hospital saw 52% increase in firearm injuries during pandemic (Links to an external site)

Children watch as St. Louis police officers investigate the shooting of their neighbor, a girl under a year old, in the 1300 block of Temple Place in Hamilton Heights on Friday, Aug. 14, 2020. The girl was reported to be shot in the arm and was taken to the hospital by officers.

ST. LOUIS — Children seen at one of the St. Louis region’s busiest pediatric hospitals suffered a significant increase in firearm injuries and deaths during the COVID-19 pandemic, according to a recent study by the University of Missouri School of Medicine in Columbia. The study looked at pediatric patients cared for at St. Louis Children’s […]

Pediatric Center of Excellence in Nephrology established with NIH funding (Links to an external site)

Physician-scientists at Washington University School of Medicine in St. Louis have received a grant from the National Institutes of Health (NIH) to establish a Pediatric Center of Excellence in Nephrology. Among the researchers' aims is to create high-definition molecular reference maps showing genetic details of normal and diseased kidneys during various stages of childhood growth and development.

Researchers at Washington University School of Medicine in St. Louis have received a grant from the National Institutes of Health (NIH) to establish a Pediatric Center of Excellence in Nephrology. The center’s physician-scientists will create high-definition molecular reference maps showing genetic details of normal and diseased kidneys during various stages of childhood growth and development. […]

Cellular housekeeping process implicated in fatal neurological disorder (Links to an external site)

A study from Washington University School of Medicine in St. Louis shows that as patients age, Huntington's disease impairs autophagy, which eliminates waste from cells. Shown at left are neurons transformed from skin cells of a young patient with pre-symptomatic Huntington's disease. On the right are neurons transformed from skin cells of an older patient with symptomatic Huntington's; these cells are sparse because the aging process impairs autophagy, leading to cell death.

Huntington’s disease, a fatal, inherited neurodegenerative condition, is caused by a genetic error present at birth, though its symptoms often don’t begin until middle adulthood. Scientists at Washington University School of Medicine in St. Louis have been trying to understand how the aging process triggers the onset of symptoms, with the expectation that such knowledge […]