Carmen Halabi, M.D., Ph.D.  chalabi@wustl.edu

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Assistant Professor of Pediatrics, Nephrology
Assistant Professor of Cell Biology and Physiology
NephrologyPediatric Research

phone: (314) 286-1574

Clinical Interests

My clinical interests include diagnosis and management of congenital anomalies of the kidney and urinary tract, chronic kidney disease, hypertension, kidney stones, urinary tract infections, glomerular diseases including nephrotic and nephritic syndromes, and electrolyte disorders. In the acute setting, as part of the dialysis and pheresis team, we provide all modalities of renal replacement therapies and therapeutic plasma exchange.

Education

  • BS, Honors and High Distinction, The University of Iowa2001
  • PhD, The University of Iowa2009
  • MD, The University of Iowa Carver College of Medicine2009

Training

  • Resident in Pediatrics, Saint Louis Children's Hospital2009 - 2011
  • Fellow in Pediatric Nephrology, Washington University School of Medicine2011 - 2015

Licensure and Board Certification

  • 2012 - PresMO, State Board of Registration for the Healing Arts - Physician and Surgeon
  • 2012 - PresAmerican Board of Pediatrics/General Pediatrics
  • 2015 - PresIL, Department of Financial and Professional Regulation - Licensed Physician and Surgeon
  • 2016 - PresThe American Board of Pediatrics/Pediatric Nephrology

Honors and Awards

  • Predoctoral Training Program in Genetics, National Institutes of Health, 5T32GM008629, PI: Jeffrey Murray, M.D.2005 - 2007
  • Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award, American Physiological Society2007
  • Research Day Award for Best Graduate Student Basic Science Poster, Department of Internal Medicine, The University of Iowa Carver College of Medicine2007
  • Research Week Poster Award, The University of Iowa Carver College of Medicine2007
  • Merck New Investigator Award, American Heart Association - Council on High Blood Pressure2007
  • Best Poster Presentation Award, The University of Iowa Genetics Ph.D. Program2007
  • Dean's Distinguished Dissertation Award, The University of Iowa2010
  • Postdoctoral Developmental Cardiology and Pulmonary Training Program, National Institutes of Health, 5T32HL007873, PI: Robert Mecham, Ph.D.2012 - 2014
  • Trainee Research Award in Pediatric Nephrology, American Society of Pediatric Nephrology2014
  • Physician Scientist Training Program, National Institutes of Health, 2T32HD043010, PI: Alan Schwartz, Ph.D., M.D.2014 - 2015
  • Pediatric Physician-Scientist Training Program Fellowship Support, Mallinckrodt Foundation2014 - 2015
  • Travel Award, American Society for Matrix Biology2014
  • "Teresa Vietti Fellow" Award, Department of Pediatrics, Washington University School of Medicine2015
  • Scholar of the Child Health Research Center at Washington University School of Medicine, National Institutes of Health, K12-HD0762242015 - 2017
  • F. Sessions Cole, M.D. Award in Clinical Excellence 20182018

Recent Publications view all (26)


Publication Co-Authors

  1. Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration. J Lipid Res. 2021;62:100079. PMCID:PMC8144742  PMID:33894211 
  2. Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency. Function (Oxf). 2021;2(3):zqab015. PMCID:PMC8248879  PMID:34223172 
  3. Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity. Sci Transl Med. 2021;13(583). PMID:33658356 
  4. Sickle cell disease-Under pressure. Pediatr Blood Cancer. 2021;e28932. PMID:33559325 
  5. Complex consequences of Cantu Syndrome SUR2 variant R1154Q in genetically modified mice. JCI Insight. 2021. PMID:33529173 
  6. Vascular elastic fiber heterogeneity in health and disease. Curr Opin Hematol. 2020;27(3):190-196. PMID:32141894 
  7. Glibenclamide reverses cardiovascular abnormalities of Cantu Syndrome driven by KATP channel overactivity. J Clin Invest. 2019. PMID:31821173 
  8. Sodium-activated potassium channels moderate excitability in vascular smooth muscle. J Physiol. 2019. PMID:31444905 
  9. Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress. JCI Insight. 2019;5. PMID:31211696 
  10. Cardiovascular consequences of KATP overactivity in Cantu syndrome. JCI Insight. 2018;3(15). PMID:30089727 
  11. Macrophage angiotensin II type 2 receptor triggers neuropathic pain. Proc Natl Acad Sci U S A. 2018. PMID:30082378 
  12. Elastin purification and solubilization. Methods Cell Biol. 2018;143:207-222. PMID:29310779 
  13. Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries. Sci Adv. 2017;3(5):e1602532. PMCID:PMC5415335  PMID:28508064 
  14. In tandem extracorporeal therapies during hemodialysis in pediatric patients. Hemodial Int. 2016;20 Suppl 1:S40-S43. PMID:27669548 
  15. Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. Proc Natl Acad Sci U S A. 2016;113(31):8759-64. PMID:27432961 
  16. Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness. Am J Physiol Heart Circ Physiol. 2015;309(5):H1008-16. doi:10.1152/ajpheart.00288.2015  PMID:26232234 
  17. Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities. J Biol Chem. 2015;290(35):21443-59. doi:10.1074/jbc.M115.640425  PMID:26178373 
  18. Aggressive blood pressure control for chronic kidney disease unmasks moyamoya! Clin Kidney J. 2013;6(5):495-9. doi:10.1093/ckj/sft090  PMCID:PMC4438405  PMID:26064513 
  19. Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta. Arterioscler Thromb Vasc Biol. 2010;30(3):518-25. doi:10.1161/ATVBAHA.109.200733  PMCID:PMC2850258  PMID:20018933 
  20. Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circ Res. 2010;106(2):373-82. doi:10.1161/CIRCRESAHA.109.208645  PMCID:PMC2818798  PMID:19926873 
  21. Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles. Physiol Genomics. 2008;35(1):1-4. doi:10.1152/physiolgenomics.90284.2008  PMCID:PMC2574738  PMID:18612081 
  22. Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ Res. 2008;103(6):654-61. doi:10.1161/CIRCRESAHA.108.176339  PMCID:PMC2583077  PMID:18676352 
  23. Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension. 2008;51(4):867-71. doi:10.1161/HYPERTENSIONAHA.107.103648  PMCID:PMC2408877  PMID:18285614 
  24. Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab. 2008;7(3):215-26. doi:10.1016/j.cmet.2007.12.008  PMCID:PMC2275166  PMID:18316027 
  25. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol. 2007;81(2):813-21. doi:10.1128/JVI.02012-06  PMCID:PMC1797474  PMID:17079315 
  26. Peroxisome proliferator-activated receptor-gamma and its agonists in hypertension and atherosclerosis : mechanisms and clinical implications. Am J Cardiovasc Drugs. 2005;5(6):389-98. PMID:16259527 
Last updated: 10/05/2021
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