Anthony W. Orvedahl, M.D., Ph.D.

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Assistant Professor of Pediatrics, Infectious Diseases
Infectious Diseases

phone: (314) 454-6050

Clinical Interests

Dr. Orvedahl cares for children with infectious diseases and associated complications. He has a particular interest in immunocompromised hosts, inborn errors of immunity, emerging viral infections, and immune dysregulation disorders including sepsis.

Dr. Orvedahl's research interests are in cell-intrinsic immunity and the role of cytosolic quality control pathways in the regulation of inflammatory responses. Current studies aim to identify the basic mechanisms underpinning cell survival during macrophage responses to the cytokines, interferon-gamma and tumor necrosis factor, and the physiological significance of these factors in models of fatal systemic inflammation, such as septic shock. Using genome-wide CRISPR/Cas9 screening approaches, we found that autophagy genes were critical to protect myeloid cells against cytokine induced cell death. Mice with myeloid cell autophagy gene deficiency also succumbed more readily to TNF-induced shock. We are using multi-omics approaches to dissect the mechanisms by which autophagy genes protect against cytokine-induced cell death in vitro and in vivo. Further, we are characterizing additional identified genes that had not been previously linked to cell death or sepsis, which implicate immunometabolism as a central regulator of these processes. Additional studies seek to understand the contributions of cytosolic nucleic acid metabolism and endogenous retroviruses during viral infections and interferon responses.


  • BA, summa cum laude, University of Colorado2004
  • MD, University of Texas - Southwestern Medical Center2012
  • PhD, University of Texas - Southwestern Medical Center2012


  • Resident in Pediatrics (ARP), St. Louis Children's Hospital2012 - 2014
  • Fellow, Pediatric Infectious Diseases, Washington University School of Medicine2014 - 2018

Licensure and Board Certification

  • 2017American Board of Pediatrics
  • 2018 - PresMO, Board of Registration for the Healing Arts
  • 2019American Board of Pediatrics, Pediatric Infectious Diseases

Honors and Awards

  • Jacob Van Ek Award for Community Service and Academic Excellence, University of Colorado2004
  • Honorable Mention, Graduate Student Poster Session, UT-Southwestern2006
  • Keystone Symposium Travel Award2006
  • Keystone Symposium Conference Assistantship, "Autophagy in Health and Disease"2007
  • Keystone Symposium Conference Assistantship, "Cell Biology of Virus Entry, Replication, and Pathogenesis"2008
  • Molecular Microbiology Graduate Program Nominee, Nominata Award (for most outstanding graduate student, UTSW)2010
  • Quality Improvement Showcase selection, St. Louis Children's Hospital Residency Program2014
  • Outstanding Poster Award, PIDS-St. Jude Pediatric ID Research Conference2019
  • Finalist, Bridging to Success Award, Society for Pediatric Research2019

Recent Publications view all (23)

Publication Co-Authors

  1. Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Commun Biol. 2022;5(1):47. PMCID:PMC8755814  PMID:35022507 
  2. Lrp1 is a host entry factor for Rift Valley fever virus. Cell. 2021;184(20):5163-5178.e24. PMCID:PMC8786218  PMID:34559985 
  3. Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity. Cell Metab. 2021;33(2):270-282.e8. PMCID:PMC7858234  PMID:33278339 
  4. UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Proc Natl Acad Sci U S A. 2021;118(1). PMCID:PMC7817147  PMID:33372156 
  5. A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes. Trends Mol Med. 2020;26(12):1078-1085. PMCID:PMC7524648  PMID:33051104 
  6. Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. Nat Microbiol. 2020;5(2):272-281. PMCID:PMC7147835  PMID:31959973 
  7. Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock. PNAS. . 2019;116(33):16497-16506. doi:DOI: 10.1073/pnas.1822157116  PMID:31346084 
  8. Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ. Nat Microbiol. 2019;4(7):1120-1128. PMCID:PMC6588490  PMID:30936486 
  9. Successful treatment of fulminant neonatal enteroviral myocarditis in monochorionic diamniotic twins with cardiopulmonary support, intravenous immunoglobulin and pocapavir. BMJ Case Rep. 2018;2018. PMID:29776940 
  10. Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine. Cell Host Microbe. 2017;22(4):449-459.e4. PMCID:PMC5679710  PMID:28966054 
  11. A 12-Year-Old Girl With Encephalopathy and Acute Flaccid Paralysis: A Neuropathological Correlation and Cohort Review. Pediatr Neurol. 2017;66:5-11. PMID:27769728 
  12. Clinical Characterization of Children Presenting to the Hospital with Enterovirus D68 Infection During the 2014 Outbreak in St. Louis. Pediatr Infect Dis J. 2016;35(5):481-7. PMCID:PMC5237429  PMID:26771663 
  13. Genome sequence of enterovirus D68 from St. Louis, Missouri, USA. Emerg Infect Dis. 2015;21(1):184-6. PMCID:PMC4285240  PMID:25532062 
  14. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature. 2011;480(7375):113-7. PMCID:PMC3229641  PMID:22020285 
  15. RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell. 2011;144(2):253-67. PMCID:PMC3038590  PMID:21241894 
  16. Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe. 2010;7(2):115-27. PMCID:PMC2860265  PMID:20159618 
  17. Autophagy in Mammalian antiviral immunity. Curr Top Microbiol Immunol. 2009;335:267-85. PMID:19802570 
  18. Eating the enemy within: autophagy in infectious diseases. Cell Death Differ. 2009;16(1):57-69. PMCID:PMC2736877  PMID:18772897 
  19. Autophagy and viral neurovirulence. Cell Microbiol. 2008;10(9):1747-56. PMCID:PMC2737270  PMID:18503639 
  20. Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis. Proc Natl Acad Sci U S A. 2008;105(34):12497-502. PMCID:PMC2527940  PMID:18713860 
  21. Viral evasion of autophagy. Autophagy. 2008;4(3):280-5. PMCID:PMC3508671  PMID:18059171 
  22. 2007 Keystone Symposium on Autophagy in Health and Disease. Autophagy. 2007;3(5):527-36. PMID:17617735 
  23. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe. 2007;1(1):23-35. PMID:18005679 
Last updated: 01/31/2022
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