David A. Rosen, M.D., Ph.D.  rosend@wustl.edu

Profile picture
Assistant Professor of Pediatrics
Researcher, Pathobiology
Infectious DiseasesMolecular Microbiology

phone: (314) 454-6050

Clinical Interests

Dr. Rosen evaluates children with a variety of infectious diseases at St. Louis Children's Hospital. He has a particular interest in the treatment of resistant Gram-negative bacterial infections.

In his research lab, Dr. Rosen studies basic pathogenic mechanisms of Klebsiella pneumoniae. This organism often carries sets of genes that render it resistant to most, if not all, available antibiotics. Klebsiella, and other carbapenem-resistant Enterobacteriales (CRE), have recently been assigned a threat level of urgent by the CDC. Utilizing mouse models of pneumonia and urinary tract infection, Dr. Rosen dissects mechanisms by which Klebsiella pneumoniae infects the host. Specific interests includes differential regulation of virulence determinants, including type 1 pili and capsule, and adaptive immune responses to Klebsiella in the lung. The ultimate goal is to develop further understanding of Klebsiella pneumoniae pathogenesis, which may reveal alternative therapies to combat these resistant organisms.


  • BS, Highest Distinction and Highest Honors, University of Michigan2002
  • MD, Washington University School of Medicine2010
  • PhD, Washington University School of Medicine2010


  • Pediatric Internship and Residency, St. Louis Children's Hospital2010 - 2012
  • Pediatric Infectious Diseases Fellowship, Washington University School of Medicine, St. Louis Children's Hospital2012 - 2016

Licensure and Board Certification

  • 2012 - PresMO, Physician and Surgeon License
  • 2013 - PresGeneral Pediatrics, American Board of Pediatrics
  • 2017 - PresPediatric Infectious Diseases, American Board of Pediatrics

Honors and Awards

  • Farmington Rotary Foundation Daniel Waldman Memorial Scholarship1998
  • State of Michigan House of Representatives Certificate of Recognition1998
  • University of Michigan Regents-Alumni Scholarship1998
  • William Beaumont Hospital Scholarship1998 - 2001
  • University of Michigan James B. Angell Scholar1999 - 2002
  • National Stark Scholarship for Chemistry and Biochemistry2001
  • American Institute of Chemistry Merit Award for Biochemistry2002
  • Washington University Medical School Teaching Assistant of the Year2007
  • Washington University Teaching Citation2008
  • Alexander Berg Prize for Microbiology Research2010
  • St. Louis Children’s Hospital Chief Resident Award2012
  • Pediatric Infectious Diseases Society Fellowship Award2013 - 2015
  • Oliver Langenberg Physician-Scientist Training Program Post-Doctoral Trainee, Washington University School of Medicine2014 - 2017
  • St. Louis Children’s Hospital Outstanding Fellow Teaching Award2015 - 2016
  • Pediatric Infectious Diseases Society Fellow Video Award2015
  • Publons Peer Review Award, Top 1% in Microbiology2018
  • St. Jude/PIDS Pediatric Infectious Diseases Research Conference Poster Award2019
  • American Association of Immunology Early Career Travel Award2020
  • American Association of Immunologists Careers in Immunology Fellowship2021 - 2022

Recent Publications view all (19)

Publication Co-Authors

  1. Discovery and characterization of a new class of O-linking oligosaccharyltransferases from the Moraxellaceae family. Glycobiology. 2022. PMID:36239418 
  2. Airway multidrug-resistant organisms in a population of tracheostomy and chronic ventilator-dependent children at a tertiary care pediatric hospital. Pediatr Pulmonol. 2022. PMID:36100968 
  3. Classical and γδ T cells are each independently sufficient to establish protection against a classical strain of Klebsiella pneumoniae. Front Cell Infect Microbiol. 2022;12:974175. PMCID:PMC9471189  PMID:36118033 
  4. Skin findings of impetigo neonatorum and staphylococcal scalded skin syndrome. J Pediatr. 2022. PMID:35977617 
  5. Murine Respiratory Tract Infection with Classical Klebsiella pneumoniae Induces Bronchus-Associated Lymphoid Tissue. Infect Immun. 2022;e0059621. PMID:35311545 
  6. Pneumococcal Empyema. N Engl J Med. 2021;385(6):548. PMID:34329546 
  7. Practical School Algorithms for Symptomatic or SARS-CoV-2-Exposed Students Are Essential for Returning Children to In-Person Learning. J Pediatr. 2020. PMCID:PMC7516575  PMID:32980377 
  8. A murine model demonstrates capsule-independent adaptive immune protection in survivors of Klebsiella pneumoniae respiratory tract infection. Dis Model Mech. 2020;13(3). PMCID:PMC7104859  PMID:32298236 
  9. A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae. Proc Natl Acad Sci U S A. 2019;116(37):18655-18663. PMCID:PMC6744904  PMID:31455739 
  10. Ureaplasma urealyticum pyelonephritis presenting with progressive dysuria, renal failure, and neurologic symptoms in an immunocompromised patient. Transpl Infect Dis. 2019;21(2):e13032. PMCID:PMC6542459  PMID:30472777 
  11. Whole-genome sequencing of Klebsiella pneumoniae isolates to track strain progression in a single patient with recurrent urinary tract infection. Front Cell Infect Microbiol. 2019;9:14. PMCID:PMC6375827  PMID:30800643 
  12. Population Structure, Antibiotic Resistance, and Uropathogenicity of Klebsiella variicola. MBio. 2018;9(6). PMCID:PMC6299229  PMID:30563902 
  13. In silico discovery of small molecules that inhibit RfaH recruitment to RNA polymerase. Mol Microbiol. 2018;110(1):128-142. PMCID:PMC6595482  PMID:30069925 
  14. High levels of cyclic di-GMP in Klebsiella pneumoniae attenuate virulence in the lung. Infect Immun. 2018;86(2). PMCID:PMC5778367  PMID:29158434 
  15. Klebsiella pneumoniae FimK promotes virulence in murine pneumonia. J Infect Dis. 2016;213(4):649-58. PMCID:PMC4721909  PMID:26347570 
  16. Streptozocin-induced diabetic mouse model of urinary tract infection. Infect Immun. 2008;76(9):4290-8. PMCID:PMC2519435  PMID:18644886 
  17. Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression. Infect Immun. 2008;76(7):3337-45. PMCID:PMC2446714  PMID:18411285 
  18. Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract. Infect Immun. 2008;76(7):3346-56. PMCID:PMC2446687  PMID:18474655 
  19. Detection of intracellular bacterial communities in human urinary tract infection. PLoS Med. 2007;4(12):e329. PMCID:PMC2140087  PMID:18092884 
Last updated: 11/29/2022
© 2022 by Washington University in St. Louis
One Brookings Drive, St. Louis, MO 63130