Jennifer Sprague, M.D., Ph.D.

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Assistant Professor of Pediatrics, Endocrinology and Diabetes
Endocrinology and Diabetes

phone: (314) 454-6051

Clinical Interests

Dr. Sprague’s clinical interests include pediatric diabetes (type 1 and type 2) and general endocrine disorders (disorders of growth, puberty, thyroid and adrenal disease). She has a particular interest in endocrine complications of obesity including type 2 diabetes, metabolic syndrome and polycystic ovary syndrome (PCOS). Dr. Sprague is active in the type 2 diabetes education and care program at St. Louis Children’s Hospital. She has a focus on patient education, patient centered outcomes and quality improvement.


  • BS, Highest Honors, Indiana University2000
  • MD, Washington University School of Medicine2007
  • PhD, Washington University School of Medicine2007


  • Pediatrics Residency, St. Louis Children's Hospital2007 - 2010
  • Pediatric Endocrinology Fellowship, Washington University2010 - 2013
  • Leadership Development Program, Washington University2015 - 2015
  • Education Skills Program, Washington University2018 - 2018
  • Fundamentals of Obesity Treatment, Obesity Medicine Association2018
  • Latest Evidence and Trends in Pediatric Obesity, Children's Healthcare of Atlanta2018
  • Advanced Therapies for Pediatric Obesity, University of Minnesota2018
  • Obesity Medicine Association Fall Summit: Overcoming Obesity, Boston, MA2019 - 2019

Licensure and Board Certification

  • 2010 - PresMO, Medicine
  • 2010 - PresGeneral Pediatrics
  • 2013 - PresPediatric Endocrinology
  • 2020 - PresAmerican Board of Obesity Medicine
  • 2021 - PresIL, Licensed Physician and Surgeon
  • 2021 - PresIL, Licensed Physician Controlled Substance

Honors and Awards

  • National Starch & Chemical Scholarship1997 - 1998
  • Lubrizol Scholarship in Chemistry1998 - 1999
  • Ronald E. McNair Post-baccalaureate Achievement Program1999 - 2000
  • Triple Crown Award - St. Louis Children's Hospital, Children's Direct2012
  • Best Abstract in Basic Research - Department of Pediatrics Research Retreat2013
  • PENS Best Case Study Poster Award: Co-author, "Suppression of Pituitary Axis from Inhaled Corticosteroids"2019

Recent Publications view all (11)

Publication Co-Authors

  1. National Trends in Pediatric Metabolic and Bariatric Surgery: 2010-2017 Pediatrics. 2022. PMID:36373280 
  2. Predictors of response to insulin therapy in youth with poorly controlled type 2 diabetes in the TODAY trial. Pediatr Diabetes. 2019. PMID:31418516 
  3. Menstrual Dysfunction in Girls from the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study. J Clin Endocrinol Metab. 2018. PMID:29697830 
  4. Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice. PLoS One. 2013;8(1):e54625. doi:10.1371/journal.pone.0054625  PMCID:PMC3551761  PMID:23349943 
  5. Vitamin D suppression of endoplasmic reticulum stress promotes an antiatherogenic monocyte/macrophage phenotype in type 2 diabetic patients. J Biol Chem. 2012;287(46):38482-94. doi:10.1074/jbc.M112.386912  PMCID:PMC3493893  PMID:23012375 
  6. Glucose counterregulatory responses to hypoglycemia. Pediatr Endocrinol Rev. 2011;9(1):463-73; quiz 474-5. PMID:22783644 
  7. Targeting the alphavbeta3 integrin for small-animal PET/CT of osteolytic bone metastases. J Nucl Med. 2009;50(11):1873-80. doi:10.2967/jnumed.109.067140  PMCID:PMC2836828  PMID:19875645 
  8. Synthesis, characterization and in vivo studies of Cu(II)-64-labeled cross-bridged tetraazamacrocycle-amide complexes as models of peptide conjugate imaging agents. J Med Chem. 2007;50(10):2527-35. doi:10.1021/jm070204r  PMID:17458949 
  9. Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a 64Cu-labeled RGD peptide. J Nucl Med. 2007;48(2):311-8. PMCID:PMC2711534  PMID:17268030 
  10. In vitro and in vivo investigation of matrix metalloproteinase expression in metastatic tumor models. Nucl Med Biol. 2006;33(2):227-37. doi:10.1016/j.nucmedbio.2005.10.011  PMID:16546677 
  11. Preparation and biological evaluation of copper-64-labeled tyr3-octreotate using a cross-bridged macrocyclic chelator. Clin Cancer Res. 2004;10(24):8674-82. doi:10.1158/1078-0432.CCR-04-1084  PMID:15623652 
Last updated: 11/15/2022
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