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Stephen Sykes
s.m.sykes@wustl.edu
Associate Professor of Pediatrics, Hematology and Oncology
Researcher, Hematology and Oncology
phone: (314) 454-6018
Education
BS,
Mount Allison University
,
2000
PhD,
University of Pennsylvannia
,
2007
Training
Post-doctoral Fellowship, Harvard Medical School - Brigham and Women's Hospital
,
2008
-
2009
Post-doctoral Fellowship, Harvard Medical School - Massachusetts General Hospital
,
2009
-
2012
Honors and Awards
Mount Allison University Entrance Scholarship
,
1997
- 1998
Academic All-Canadian - Basketball
,
2000
Monica Shander Award for Outstanding Pre-Doctoral Research (Wistar Institute)
,
2006
International Society of Experimental Hematology (ISEH) Eugene Goldwasser Fellowship
,
2011
- 2012
American Society of Hematology (ASH) Junior Scholar Award
,
2014
- 2016
American Cancer Society Research Scholar Award
,
2019
- 2022
Recent Publications
view all (43)
Maifrede S, Le BV, Nieborowska-Skorska M, Golovine K, Sullivan-Reed K, Dunuwille WMB, Nacson J, Hulse M, Keith K, Madzo J, Caruso LB, Gazze Z, Lian Z, Padella A, Chitrala KN, Bartholdy BA, Matlawska-Wasowska K, Di Marcantonio D, Simonetti G, Greiner G, Sykes SM, Valent P, Paietta EM, Tallman MS, Fernandez HF, Litzow MR, Minden MD, Huang J, Martinelli G, Vassiliou GS, Tempera I, Piwocka K, Johnson N, Challen GA, Skorski T.
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
Cancer Res
.
2021.
PMID:
34215619
Di Marcantonio D, Martinez E, Kanefsky JS, Huhn JM, Gabbasov R, Gupta A, Krais JJ, Peri S, Tan Y, Skorski T, Dorrance A, Garzon R, Goldman AR, Tang HY, Johnson N, Sykes SM.
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Mol Cell
.
2021;81
(13):
2752-2764.e6.
PMID:
34081901
Stanek TJ, Gennaro VJ, Tracewell MA, Di Marcantonio D, Pauley KL, Butt S, McNair C, Wang F, Kossenkov AV, Knudsen KE, Butt T, Sykes SM, McMahon SB.
The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22.
EMBO J
.
2021;e102509.
PMID:
34155658
Nacson J, Di Marcantonio D, Wang Y, Bernhardy AJ, Clausen E, Hua X, Cai KQ, Martinez E, Feng W, Callén E, Wu W, Gupta GP, Testa JR, Nussenzweig A, Sykes SM, Johnson N.
BRCA1 Mutational Complementation Induces Synthetic Viability.
Mol Cell
.
2020;78
(5):
951-959.e6.
PMCID:
PMC7418109
PMID:
32359443
Peshkova IO, Aghayev T, Fatkhullina AR, Makhov P, Titerina EK, Eguchi S, Tan YF, Kossenkov AV, Khoreva MV, Gankovskaya LV, Sykes SM, Koltsova EK.
IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development.
Nat Commun
.
2019;10
(1):
5046.
PMCID:
PMC6834661
PMID:
31695038
Di Marcantonio D, Sykes SM.
Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia.
J Vis Exp
.
2019;(151).
PMCID:
PMC7239511
PMID:
31545325
Sykes SM.
NCAM1 supports therapy resistance and LSC function in AML.
Blood
.
2019;133
(21):
2247-2248.
PMID:
31122937
Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N.
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
Cell Rep
.
2018;25
(5):
1384.
PMCID:
PMC6296467
PMID:
30380426
Rudat S, Pfaus A, Cheng YY, Holtmann J, Ellegast JM, Bühler C, Marcantonio DD, Martinez E, Göllner S, Wickenhauser C, Müller-Tidow C, Lutz C, Bullinger L, Milsom MD, Sykes SM, Fröhling S, Scholl C.
RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia.
Leukemia
.
2018;32
(10):
2189-2202.
PMID:
29654265
Masselli E, Carubbi C, Cambò B, Pozzi G, Gobbi G, Mirandola P, Follini E, Pagliaro L, Di Marcantonio D, Bonatti F, Percesepe A, Sykes SM, Aversa F, Vitale M.
The -2518 A/G polymorphism of the monocyte chemoattractant protein-1 as a candidate genetic predisposition factor for secondary myelofibrosis and biomarker of disease severity.
Leukemia
.
2018;32
(10):
2266-2270.
PMCID:
PMC6170394
PMID:
29568096
Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N.
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
Cell Rep
.
2018;24
(13):
3513-3527.e7.
PMCID:
PMC6219632
PMID:
30257212
Maifrede S, Nieborowska-Skorska M, Sullivan-Reed K, Dasgupta Y, Podszywalow-Bartnicka P, Le BV, Solecka M, Lian Z, Belyaeva EA, Nersesyan A, Machnicki MM, Toma M, Chatain N, Rydzanicz M, Zhao H, Jelinek J, Piwocka K, Sliwinski T, Stoklosa T, Ploski R, Fischer T, Sykes SM, Koschmieder S, Bullinger L, Valent P, Wasik MA, Huang J, Skorski T.
Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors.
Blood
.
2018;132
(1):
67-77.
PMCID:
PMC6034642
PMID:
29784639
Di Marcantonio D, Martinez E, Sidoli S, Vadaketh J, Nieborowska-Skorska M, Gupta A, Meadows JM, Ferraro F, Masselli E, Challen GA, Milsom MD, Scholl C, Fröhling S, Balachandran S, Skorski T, Garcia BA, Mirandola P, Gobbi G, Garzon R, Vitale M, Sykes SM.
Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia.
Clin Cancer Res
.
2018;24
(3):
608-618.
PMCID:
PMC5796864
PMID:
29127121
Maifrede S, Martinez E, Nieborowska-Skorska M, Di Marcantonio D, Hulse M, Le BV, Zhao H, Piwocka K, Tempera I, Sykes SM, Skorski T.
MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs.
Blood Adv
.
2017;1
(19):
1467-1472.
PMCID:
PMC5728460
PMID:
29296788
Nieborowska-Skorska M, Sullivan K, Dasgupta Y, Podszywalow-Bartnicka P, Hoser G, Maifrede S, Martinez E, Di Marcantonio D, Bolton-Gillespie E, Cramer-Morales K, Lee J, Li M, Slupianek A, Gritsyuk D, Cerny-Reiterer S, Seferynska I, Stoklosa T, Bullinger L, Zhao H, Gorbunova V, Piwocka K, Valent P, Civin CI, Muschen M, Dick JE, Wang JC, Bhatia S, Bhatia R, Eppert K, Minden MD, Sykes SM, Skorski T.
Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells.
J Clin Invest
.
2017;127
(6):
2392-2406.
PMCID:
PMC5451241
PMID:
28481221
Zhou C, Martinez E, Di Marcantonio D, Solanki-Patel N, Aghayev T, Peri S, Ferraro F, Skorski T, Scholl C, Fröhling S, Balachandran S, Wiest DL, Sykes SM.
JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia.
Leukemia
.
2017;31
(5):
1196-1205.
PMCID:
PMC5473421
PMID:
27840425
Monteith JA, Mellert H, Sammons MA, Kuswanto LA, Sykes SM, Resnick-Silverman L, Manfredi JJ, Berger SL, McMahon SB.
A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction.
Mol Oncol
.
2016;10
(8):
1207-20.
PMCID:
PMC5423199
PMID:
27341992
Sykes SM.
The identity crisis of Hif-1α in HSC biology.
Blood
.
2016;127
(23):
2782-4.
PMID:
27282941
Sykes SM, Kokkaliaris KD, Milsom MD, Levine RL, Majeti R.
Clonal evolution of preleukemic hematopoietic stem cells in acute myeloid leukemia.
Exp Hematol
.
2015;43
(12):
989-92.
PMCID:
PMC5492948
PMID:
26455528
Di Marcantonio D, Galli D, Carubbi C, Gobbi G, Queirolo V, Martini S, Merighi S, Vaccarezza M, Maffulli N, Sykes SM, Vitale M, Mirandola P.
PKCε as a novel promoter of skeletal muscle differentiation and regeneration.
Exp Cell Res
.
2015;339
(1):
10-9.
PMCID:
PMC5130411
PMID:
26431586
Limon JJ, So L, Jellbauer S, Chiu H, Corado J, Sykes SM, Raffatellu M, Fruman DA.
mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.
Proc Natl Acad Sci U S A
.
2014;111
(47):
E5076-85.
PMCID:
PMC4250172
PMID:
25385646
Lee D, Sykes SM, Kalaitzidis D, Lane AA, Kfoury Y, Raaijmakers MH, Wang YH, Armstrong SA, Scadden DT.
Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors.
Stem Cell Reports
.
2014;3
(5):
832-40.
PMCID:
PMC4235746
PMID:
25418727
Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT.
Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Blood
.
2014;124
(19):
2937-47.
PMCID:
PMC4224192
PMID:
25202142
Placke T, Faber K, Nonami A, Putwain SL, Salih HR, Heidel FH, Krämer A, Root DE, Barbie DA, Krivtsov AV, Armstrong SA, Hahn WC, Huntly BJ, Sykes SM, Milsom MD, Scholl C, Fröhling S.
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
Blood
.
2014;124
(1):
13-23.
PMCID:
PMC4190617
PMID:
24764564
Gobbi G, Mirandola P, Carubbi C, Masselli E, Sykes SM, Ferraro F, Nouvenne A, Thon JN, Italiano JE Jr, Vitale M.
Proplatelet generation in the mouse requires PKCε-dependent RhoA inhibition.
Blood
.
2013;122
(7):
1305-11.
PMCID:
PMC3952532
PMID:
23838351
Sykes SM, Scadden DT.
Modeling human hematopoietic stem cell biology in the mouse.
Semin Hematol
.
2013;50
(2):
92-100.
PMCID:
PMC3826087
PMID:
24216169
Faber K, Bullinger L, Ragu C, Garding A, Mertens D, Miller C, Martin D, Walcher D, Döhner K, Döhner H, Claus R, Plass C, Sykes SM, Lane SW, Scholl C, Fröhling S.
CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling.
J Clin Invest
.
2013;123
(1):
299-314.
PMCID:
PMC3533294
PMID:
23202735
Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA, Armstrong SA.
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.
Cell Stem Cell
.
2012;11
(3):
429-39.
PMCID:
PMC3743253
PMID:
22958934
Ferraro F, Lymperi S, Méndez-Ferrer S, Saez B, Spencer JA, Yeap BY, Masselli E, Graiani G, Prezioso L, Rizzini EL, Mangoni M, Rizzoli V, Sykes SM, Lin CP, Frenette PS, Quaini F, Scadden DT.
Diabetes impairs hematopoietic stem cell mobilization by altering niche function.
Sci Transl Med
.
2011;3
(104):
104ra101.
PMCID:
PMC3754876
PMID:
21998408
Lane SW, Wang YJ, Lo Celso C, Ragu C, Bullinger L, Sykes SM, Ferraro F, Shterental S, Lin CP, Gilliland DG, Scadden DT, Armstrong SA, Williams DA.
Differential niche and Wnt requirements during acute myeloid leukemia progression.
Blood
.
2011;118
(10):
2849-56.
PMCID:
PMC3172801
PMID:
21765021
Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT.
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Cell
.
2011;146
(5):
697-708.
PMCID:
PMC3826540
PMID:
21884932
Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher T.
Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.
Blood
.
2011;118
(5):
1264-73.
PMCID:
PMC3152494
PMID:
21653327
Mellert HS, Stanek TJ, Sykes SM, Rauscher FJ 3rd, Schultz DC, McMahon SB.
Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis.
J Biol Chem
.
2011;286
(6):
4264-70.
PMCID:
PMC3039376
PMID:
21148320
Parmar K, Kim J, Sykes SM, Shimamura A, Stuckert P, Zhu K, Hamilton A, Deloach MK, Kutok JL, Akashi K, Gilliland DG, D'andrea A.
Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.
Stem Cells
.
2010;28
(7):
1186-95.
PMCID:
PMC2910804
PMID:
20506303
Lane SW, Sykes SM, Al-Shahrour F, Shterental S, Paktinat M, Lo Celso C, Jesneck JL, Ebert BL, Williams DA, Gilliland DG.
The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS.
Blood
.
2010;115
(17):
3489-97.
PMCID:
PMC2867262
PMID:
20197553
Sykes SM, Stanek TJ, Frank A, Murphy ME, McMahon SB.
Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53.
J Biol Chem
.
2009;284
(30):
20197-205.
PMCID:
PMC2740446
PMID:
19494119
Pietsch EC, Sykes SM, McMahon SB, Murphy ME.
The p53 family and programmed cell death.
Oncogene
.
2008;27
(50):
6507-21.
PMCID:
PMC2657599
PMID:
18955976
Zhang XY, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, Thorne AW, Berger SL, McMahon SB.
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.
Mol Cell
.
2008;29
(1):
102-11.
PMCID:
PMC2254522
PMID:
18206973
Mellert H, Sykes SM, Murphy ME, McMahon SB.
The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain.
Cell Cycle
.
2007;6
(11):
1304-6.
PMID:
17534149
Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB.
Acetylation of the p53 DNA-binding domain regulates apoptosis induction.
Mol Cell
.
2006;24
(6):
841-51.
PMCID:
PMC1766330
PMID:
17189187
Schnepp RW, Mao H, Sykes SM, Zong WX, Silva A, La P, Hua X.
Menin induces apoptosis in murine embryonic fibroblasts.
J Biol Chem
.
2004;279
(11):
10685-91.
PMCID:
PMC2858560
PMID:
14688275
Jin S, Mao H, Schnepp RW, Sykes SM, Silva AC, D'Andrea AD, Hua X.
Menin associates with FANCD2, a protein involved in repair of DNA damage.
Cancer Res
.
2003;63
(14):
4204-10.
PMID:
12874027
La P, Morgan TA, Sykes SM, Mao H, Schnepp RW, Petersen CD, Hua X.
Fusion proteins of retinoid receptors antagonize TGF-beta-induced growth inhibition of lung epithelial cells.
Oncogene
.
2003;22
(2):
198-210.
PMID:
12527889
Last updated: 09/16/2021
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