Juliane Bubeck Wardenburg, M.D., Ph.D.  jbubeck@wustl.edu

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Division Chief, Critical Care Medicine
Donald B. Strominger Professor
Researcher, Pediatric Research
Critical Care MedicinePediatric Research

phone: (314) 454-2527

Education

  • BA, Washington University1993
  • PhD, Washington University School of Medicine2001
  • MD, Washington University School of Medicine2001

Training

  • Pediatric Residency Training Program, University of Chicago Children's Hospital2001 - 2004
  • Pediatric Critical Care Fellowship Program, University of Chicago Children's Hospital2004 - 2008
  • Pediatric Scientist Development Program Fellow, University of Chicago2005 - 2008

Licensure and Board Certification

  • 2004 - PresIL, Licensed Physician
  • 2004 - 2014American Board of Pediatrics, General Pediatrics
  • 2008 - PresAmerican Board of Pediatrics, Pediatric Critical Care Medicine
  • 2017 - PresMO, Licensed Physician

Honors and Awards

  • The Marion Smith Spector Award for Undergraduate Research1993
  • Spencer T. and Ann W. Olin Medical Scientist Fellow1999
  • Pediatric Intern of the Year2001 - 2002
  • Summa Cum Laude, Washington University2003
  • Pediatric Senior Resident of the Year2003 - 2004
  • Pediatric Scientist Development Program Fellow2005 - 2008
  • Pediatric Fellow Teaching Award2008
  • Society for Pediatric Research Young Investigator Award2011
  • Special Emphasis Panel Reviewer, NIAID Partnerships for Biodefense2011
  • University of Chicago Distinguished Investigator Award2011
  • Burroughs Wellcome Investigators in the Pathogenesis of Infectious Disease2012
  • Elected to the American Society for Clinical Investigation2012
  • Reviewer, NCCAM/NIH Mechanistic Research on CAM Natural Products2012
  • Ricketts Symposium Lecturer, University of Chicago2012
  • Ricketts Symposium Lecturer, University of Chicago2012
  • Shipley Lecturer, Harvard Medical School2012
  • Reviewer, NIH Clinical Research and Field Studies2013 - Pres
  • Richard M. Rothberg Faculty Award for Excellence in Patient Care and Resident Education2013
  • Frontiers in Science Lecturer, American Medical School Pediatric Department Chairs Meeting2014
  • Academic Leadership Program Fellow, Committee on Institutional Collaboration, The University of Chicago2014 - 2015
  • Association of American Medical Colleges Council of Faculty and Academic Societies Representative, The University of Chicago2014 - 2016
  • Elected Representative, Faculty Advisory Committee on Translational Studies, The University of Chicago2015 - 2016
  • Alpha Omega Alpha (AOA) Honor Medical Society2018
  • Elected to the Society for Pediatric Research2019
  • Vice Chair, Gordon Research Conference on Staphylococcal Diseases2019
  • Academic Women’s Network Mentor Award, Washington University2019
  • Association of American Physicians2020

Recent Publications view all (21)


Publication Co-Authors

  1. HOME2: household vs. personalized decolonization in households of children with methicillin-resistant Staphylococcus aureus skin and soft tissue infection – a randomized clinical trial. Clin Infect Dis. 2021;73(1):e4568-e4577. PMCID:PMC8653631  PMID: 32521007 
  2. Environmental methicillin-resistant Staphylococcus aureus contamination is associated with persistent colonization and subsequent skin and soft tissue infection. JAMA Pediatr. 2020;174(6):552-562. PMCID:PMC7105954  PMID: 32227144 
  3. Staphylococcus aureus alpha-toxin suppresses antigen-specific T cell responses. J Clin Invest. 2020;130(3):1122-1127. 
  4. Longitudinal, strain specific Staphylococcus aureus introduction and transmission events in a prospective cohort study of households with community-associated methicillin-resistant S. aureus skin and soft tissue infection. Lancet Infect Dis. 2020;20(2):188-198. PMCID:PMC6995751  PMID:31784369 
  5. Interplay of personal, pet, and environmental colonization in households affected by community-associated methicillin-resistant Staphylococcus aureus. J Infect. 2019;78(3):200-207. PMCID:PMC6408279  PMID:30503843 
  6. Staphylococcus aureus alpha toxin activates Notch in vascular cells. Angiogenesis. 2019;22(1):197-209. PMCID:PMC6360126  PMID:30324336 
  7. Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness Clin Infect Dis. 2019;68(3):365-372. PMCID:PMC6336914  PMID:29893805 
  8. Comprehensive modeling reveals proximity, seasonality, and hygiene practices as key determinants of MRSA colonization in exposed households Pediatr Res. 2018;84(5):668-676. PMCID:PMC6294678  PMID:30135590 
  9. α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis Cell Host and Microbe. 2018;24(2):271-284. PMCID:PMC6295203  PMID:30033122 
  10. Staphylococcus aureus alpha toxin activates Notch in endothelial cells Cancer Research. 2018;78(13 Suppl):2055. 
  11. A Two-Component System Regulates Bacteroides fragilis Toxin to Maintain Intestinal Homeostasis and Prevent Lethal Disease. Cell Host Microbe. 2017. PMID:28943327 
  12. The Bacteroides fragilis pathogenicity island links virulence and strain competition. Gut Microbes. 2017;8(4):374-383. PMCID:PMC5570422  PMID:28632016 
  13. Staphylococcus aureus pore-forming toxins: The interface of pathogen and host complexity. Semin Cell Dev Biol. 2017. PMID:28445785 
  14. Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies. Pediatr Crit Care Med. 2017;18(3_suppl Suppl 1):S67-S82. PMCID:PMC5333132  PMID:28248836 
  15. Staphylococcus aureus in the Intensive Care Unit: Are These Golden Grapes Ripe for a New Approach? J Infect Dis. 2017;215(suppl_1):S64-S70. PMID:28003353 
  16. Staphylococcus aureus α-Toxin Response Distinguishes Respiratory Virus-Methicillin-Resistant S. aureus Coinfection in Children. J Infect Dis. 2016;214(11):1638-1646. PMCID:PMC5144732  PMID:27651418 
  17. Strain competition restricts colonization of an enteric pathogen and prevents colitis. EMBO Rep. 2016;17(9):1281-91. PMCID:PMC5007561  PMID:27432285 
  18. Activation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain. Biochemistry. 2016;55(29):4077-84. PMCID:PMC5053104  PMID:27379832 
  19. Auto-Assembling Detoxified Staphylococcus aureus Alpha-Hemolysin Mimicking the Wild-Type Cytolytic Toxin. Clin Vaccine Immunol. 2016;23(6):442-50. PMCID:PMC4895005  PMID:27030589 
  20. Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice. Nat Med. 2016;22(5):563-7. PMCID:PMC4860040  PMID:27089515 
  21. Streptolysin O rapidly impairs neutrophil oxidative burst and antibacterial responses to group A Streptococcus. Front immunol. 2015;6:581. PMCID:PMC4644796  PMID:26635795 
Last updated: 09/01/2022
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