Xunjun Xiao, Ph.D  xunjun.xiao@wustl.edu

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Assistant Professor of Pediatrics, Gastroenterology, Hepatology and Nutrition
Gastroenterology, Hepatology and Nutrition

phone: (314) 454-6173

Education

  • BSc, China Agricultural University, Beijing, China1998
  • MSc, China Agricultural University, Beijing, China2001
  • PhD, Virginia Tech2005

Training

  • Post-doc Associate, University of Pittsburgh2006 - 2009

Honors and Awards

  • Second-prize Scholarship China Agricultural University1994 - 1998
  • Yantai Scholarship China Agricultural University1997
  • Pratt Fellowship Virginia Tech2001 - 2005
  • Pitt Innovator Award University of Pittsburgh2014

Recent Publications view all (22)


Publication Co-Authors

  1. The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity. J Biol Chem. 2021;296:100661. PMCID:PMC8692231  PMID:33862081 
  2. Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding. Hum Mutat. 2020;41(11):1967-1978. PMCID:PMC7663422  PMID:32906201 
  3. Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis. Am J Gastroenterol. 2019;114(6):974-983. PMCID:PMC6624845  PMID:30789418 
  4. A carboxyl ester lipase (CEL) mutant causes chronic pancreatitis by forming intracellular aggregates that activate apoptosis. J Biol Chem. 2017;292(19):7744. PMCID:PMC5427256  PMID:28500240 
  5. A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis. J Biol Chem. 2016;291(44):23224-23236. PMCID:PMC5087739  PMID:27650499 
  6. The β5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2). J Biol Chem. 2015;290(48):28847-56. PMCID:PMC4661400  PMID:26494624 
  7. A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding. Biochim Biophys Acta. 2015;1852(7):1372-9. PMCID:PMC4645278  PMID:25862608 
  8. Porcine pancreatic lipase related protein 2 has high triglyceride lipase activity in the absence of colipase. Biochim Biophys Acta. 2013;1831(9):1435-41. PMCID:PMC3742628  PMID:23770034 
  9. Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. Pediatr Res. 2013;74(2):127-32. PMCID:PMC3737390  PMID:23732775 
  10. Identification of amino acids in human colipase that mediate adsorption to lipid emulsions and mixed micelles. Biochim Biophys Acta. 2013;1831(6):1052-9. PMCID:PMC3642234  PMID:23470256 
  11. The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding. J Lipid Res. 2013;54(2):514-21. PMCID:PMC3837459  PMID:23204298 
  12. Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns. J Biol Chem. 2011;286(30):26353-63. PMCID:PMC3143598  PMID:21652702 
  13. Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion. J Lipid Res. 2011;52(5):982-90. PMCID:PMC3073462  PMID:21382969 
  14. Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis. Hepatology. 2010;51(6):2077-85. PMCID:PMC3733097  PMID:20512995 
  15. Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt. J Biol Chem. 2009;284(21):14157-64. PMCID:PMC2682864  PMID:19346257 
  16. Cytokine mRNA expression in the small intestine of weanling pigs fed diets supplemented with specialized protein or peptide sources. Asian-Australasian J. Anim. Sci.. 2008;21(12):1800-1806. 
  17. A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides. J Lipid Res. 2007;48(11):2478-84. PMCID:PMC3684974  PMID:17715423 
  18. Effect of addition levels of Ranunculaceous plant extract on kinetics of rumen microbial fermentation in vitro. Chinese J. Anim. Sci.. 2007;43(5):27-31. 
  19. Effect of Ranunculaceous plant extract, monensin and malic acid on in vitro fermentation of wheat flour. Chinese J. Anim. Nutrition. 2007;19(1):71-75. 
  20. Numeration of Lactic acid bacteria, Bifidobacteria and Escherichia coli population in gastrointestinal track of growing pigs. J. China Agricultural Univ.. 2001;6(5):81-86. 
  21. Ruminal acidosis and its preventive measures. Chinese J. Anim. Sci.. 2001;37(5):50-52. 
  22. Treatment of wheat straw with microorganisms and nutritive values of the treated straw as feeds for growing beef cattle. Chinese J. Anim. Sci.. 1999;35(6):3-5. 
Last updated: 06/12/2022
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