John C. Lin, M.D.

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Associate Professor of Pediatrics, Critical Care Medicine
Critical Care Medicine

phone: (314) 454-2527

Clinical Interests

Dr. Lin earned his Bachelor of Arts degree in Biochemistry and English (1994) and his Medical Degree (1998) at the University of Virginia. After completing his pediatric residency in the United States Air Force, he spent one year as a general pediatrician at Osan Air Base, South Korea providing general pediatric outpatient and inpatient care to U.S. military dependents. He then completed his pediatric critical care fellowship at The Children’s Hospital of Pittsburgh and completed his remaining military service obligation in the Air Force’s largest pediatric intensive care unit in San Antonio, TX. There, he became the Chief of Pediatric Critical Care Services for the San Antonio Military Medical Consortium and worked with the GME, physician, and ancillary service leadership in the Air Force and Army to develop clinical practice guidelines, multidisciplinary training programs, simulation scenarios, and transfer criteria to best meet the medical as well as unique military needs of his patient population while addressing the challenges of high personnel turnover inherent with military reassignments and deployments. Since arriving at Washington University in 2011, he has continued his leadership in program development and implementation of unit- and hospital-wide initiatives using process improvement methods and emphasizing multi-professional collaboration. His clinical areas of interest lie in evaluating interventions that impact the course of critically ill patients, particularly those with respiratory failure or sepsis, in three distinct areas: (1) identification of unique clinical or diagnostic characteristics within broadly heterogeneous disease presentations that allow for exploration of potential targeted therapies; (2) implementation of specific task-based processes that prevent potentially harmful events or increase team performance; and (3) systems-based interventions that result in positive culture and behavior changes. These efforts have led to development and implementation of respiratory therapist driven care paths, a comprehensive transfusion and anti-coagulation approach for patients on ECMO, and a national multicenter initiative to promote early mobilization in critically ill children by maximizing multi-professional collaboration and family engagement.


  • BA, Distinction, University of Virginia1994
  • MD, University of Virginia1998


  • Pediatric Internship and Residency, San Antonio Uniformed Services Health Education Consortium Pediatric Residency1998 - 2001
  • Pediatric Critical Care Fellowship, Children’s Hospital of Pittsburgh2002 - 2005

Licensure and Board Certification

  • 2000 - 2010VA, Commonwealth of Virginia
  • 2001 - PresPediatrics, American Board of Pediatrics, 073256
  • 2005 - 2009Advanced Trauma Life Support
  • 2005 - 2010PA, Commonwealth of Pennsylvania
  • 2006 - PresPediatric Critical Care Medicine, American Board of Pediatrics, 1381
  • 2006 - 2010TX, State of Texas
  • 2008 - 2012Pediatric Advanced Life Support, Training Site Faculty, Military Training Network, Lackland AFB, TX
  • 2010 - 2012AZ, State of Arizona
  • 2011 - PresMO, State of Missouri
  • 2013 - 2017Pediatric Advanced Life Support, Instructor, BJC Healthcare, St. Louis, MO
  • 2014 - 2016Basic Life Support
  • 2014 - 2018Advanced Cardiac Life Support

Honors and Awards

  • Air Force Achievement Medal2001
  • Air Force Commendation Medal2002
  • Fellow of the Year Award, Children’s Hospital of Pittsburgh2004
  • Educational Scholarship, 34th Annual Critical Care Congress, Phoenix, AZ2005
  • Research Citation Finalist, 34th Annual Critical Care Congress, Phoenix, AZ2005
  • Semi-finalist, Margileth Award, 2005 Uniformed Services Pediatric Seminar, San Antonio, TX2005
  • Air Force Achievement Medal2008
  • Faculty Excellence Award, San Antonio Military Pediatric Consortium2009
  • Outstanding Resident Teaching Award, San Antonio Military Pediatric Consortium2009
  • Air Force Meritorious Service Medal2011
  • Attending of the Year-Pediatric Intensive Care Unit, St. Louis Children's Hospital2016

Recent Publications view all (45)

Publication Co-Authors

  1. Measuring Social Health Following Pediatric Critical Illness: A Scoping Review and Conceptual Framework J Intensive Care Med. 2022;Epub ahead of print. doi:10.1177/08850666221102815  PMID:35603750 
  2. Association of Diagnostic Stewardship for Blood Cultures in Critically Ill Children With Culture Rates, Antibiotic Use, and Patient Outcomes: Results of the Bright STAR Collaborative. JAMA Pediatr. 2022;Online ahead of print. doi:10.1001/jamapediatrics.2022.1024  PMID:35499841 
  3. Thromboelastography profiles in critically ill children with multisystem inflammatory syndrome Pediatr Blood Cancer. 2022;69(5):e29426. doi:10.1002/pbc.29426  PMID:34941014 
  4. Numbers and narratives: how qualitative methods can strengthen the science of paediatric antimicrobial stewardship JAC Antimicrob Resist. 2022;4(1). doi:10.1093/jacamr/dlab195  PMCID:PMC8794647  PMID:35098126 
  5. Prevalence of Pathogenic and Potentially Pathogenic Inborn Error of Immunity Associated Variants in Children with Severe Sepsis J Clin Immunol. 2022;ePub ahead of print. doi:10.1007/s10875-021-01183-4  PMCID:PMC8720168  PMID:34973142 
  6. ABCDEF Bundle Practices for Critically Ill Children: An International Survey of 161 PICUs in 18 Countries Crit Care Med. 2022;50(1):114-125. doi:10.1097/CCM.0000000000005168  PMID:34259659 
  7. Outcomes Associated with Early RBC Transfusion in Pediatric Severe Sepsis: A Propensity-Adjusted Multicenter Cohort Study Shock. 2022;57(1):88-94. doi:10.1097/SHK.0000000000001863  PMID:34628452 
  8. Thromboelastography profiles in critically ill children with multisystem inflammatory syndrome Pediatr Blood Cancer. 2021;e29426. doi:10.1002/pbc.29426  PMID:34941014 
  9. Adherence to Lung-Protective Ventilation Principles in Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study Crit Care Med. 2021;49(10):1779-1789. doi:10.1097/CCM.0000000000005060  PMCID:PMC8448899  PMID:34259438 
  10. Consensus Recommendations for Blood Culture Use in Critically Ill Children Using a Modified Delphi Approach Pediatr Crit Care Med. 2021;22(9):774-784. doi:10.1097/PCC.0000000000002749  PMCID:PMC8416691  PMID:33899804 
  11. The Clinical Sustainability Assessment Tool: measuring organizational capacity to promote sustainability in healthcare Implement Sci Commun. 2021;2(1):77-. doi:10.1186/s43058-021-00181-2  PMCID:PMC8285819  PMID:34274004 
  12. Assessing Pain, Both Spontaneous Awakening and Breathing Trials, Choice of Sedation, Delirium Monitoring/Management, Early Exercise/Mobility, and Family Engagement/Empowerment Bundle Practices for Critically Ill Children: An International Survey of 161 PICUs in 18 Countries Crit Care Med. 2021;Online ahead of print. doi:10.1097/CCM.0000000000005168  PMID:34259659 
  13. Context-Responsive Anticoagulation is Associated with Reduced Complications and Transfusion in Neonatal and Pediatric ECMO. Front Cardiovasc Med. 2021;8. doi:10.3389/fcvm.2021.637106  PMID:34179125 
  14. Seizures are associated with brain injury in infants undergoing extracorporeal membrane oxygenation. J Child Neuro. 2021;36(3):230-236. doi:10.1177/0883073820966917  PMID:33112194 
  15. Postdischarge Outcome Domains in Pediatric Critical Care and the Instruments Used to Evaluate Them: A Scoping Review. Crit Care Med. 2020;48(12):e1313-e1321. doi:10.1097/CCM.0000000000004595  PMID:33009099 
  16. Delayed Development of Coronary Artery Dilitation in Suspected Severe Acute Respiratory Syndrome Coronavirus 2 Multisystem Inflammatory Syndrome: More Research Needed Crit Care Explor. 2020;2(10):e0236. doi:10.1097/CCE.0000000000000236  PMCID:PMC7531755  PMID:33063036 
  17. Strategies to Optimize ICU Liberation (A to F) Bundle Performance in Critically Ill Adults with Coronavirus Disease 2019 Crit Care Explor. 2020;2(6):e0139. doi:10.1097/CCE.0000000000000139  PMCID:PMC7314345  PMID:32696002 
  18. Coronavirus Disease 2019: Harnessing Healthy Fear via Knowledge, Attitudes, and Behavior Crit Care Explor. 2020;2(6):e0149. doi:10.1097/CCE.0000000000000149  PMCID:PMC7314339  PMID:32696012 
  19. Predicting Mortality in Children With Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study Crit Care Med. 2020;48(6):e514-e522. doi:10.1097/CCM.0000000000004345  PMID:32271186 
  20. Physical Rehabilitation in Critically Ill Children: A Multicenter Point Prevalence Study in the United States 2020;48(5):634-644. doi:10.1097/CCM.0000000000004291  PMID:32168030 
  21. High-flow Nasal Cannula May Be No Safer Than Non-Invasive Positive Pressure Ventilation for COVID-19 Patients Crit Care. 2020;24(1). doi:10.1186/s13054-020-02892-9  PMCID:PMC7179373  PMID:32326959 
  22. Best Practices for Conducting Interprofessional Team Rounds to Facilitate Performance of the ICU Liberation (ABCDEF) Bundle Crit Care Med. 2020;48(4):562-570. doi:10.1097/CCM.0000000000004197  PMID:32205603 
  23. Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control. J Pediatr. 2020;218:57-63. doi:10.1016/j.jpeds.2019.10.055  PMID:31910992 
  24. Early Enteral Nutrition Is Associated With Improved Clinical Outcomes in Critically Ill Children: A Secondary Analysis of Nutrition Support in the Heart and Lung Failure-Pediatric Insulin Titration Trial Pediatr Crit Care Med. 2020;21(3):213-221. doi:10.1097/PCC.0000000000002135  PMCID:PMC7060827  PMID:31577692 
  25. Practices, Perceptions, and Attitudes in the Evaluation of Critically Ill Children for Bacteremia: A National Survey Pediatr Crit Care Med. 2020;21(1):e23-e29. doi:10.1097/PCC.0000000000002176  PMCID:PMC6942229  PMID:31702704 
  26. Practices, Perceptions, and Attitudes in the Evaluation of Critically Ill Children for Bacteremia: A National Survey Pediatr Crit Care Med. 2020;21(1):e23-e29. doi:10.1097/PCC.0000000000002176  PMCID:PMC6942229  PMID:31702704 
  27. Outcomes Associated With Multiple Organ Dysfunction Syndrome in Critically Ill Children With Hyperglycemia Pediatr Crit Care Med. 2019;20(12):1147-1156. doi:10.1097/PCC.0000000000002151  PMCID:PMC6895434  PMID:31688812 
  28. Thromboelastography Variables, Immune Markers, and Endothelial Factors Associated With Shock and NPMODS in Children With Severe Sepsis Front Pediatr. 2019;7:422. doi:10.3389/fped.2019.00422  PMCID:PMC6814084  PMID:31681719 
  29. A Multicenter Network Assessment of Three Inflammation Phenotypes in Pediatric Sepsis-Induced Multiple Organ Failure. Pediatric Crit Care. 2019. doi:10.1097/PCC.0000000000002105  PMID:31568246 
  30. Development of an Antibiotic Guideline for Children With Suspected Ventilator- Associated Infections Pediatr Crit Care Med. 2019;20(8):697-706. doi:10.1097/PCC.0000000000001942  PMID:30985606 
  31. Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children 2019;47(5):706-714. doi:10.1097/CCM.0000000000003699  PMID:30789401 
  32. Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study Lancet Respir Med. 2019;7(2):115-128. doi:10.1016/S2213-2600(18)30344-8  PMCID:PMC7045907  PMID:30361119 
  33. Development of a structured outcomes assessment and implementation program in the pediatric intensive care unit. Am J Med Qual. 2018. doi:10.1177/1062860618788173  PMID:30009638 
  34. The 2014 American College of Critical Care Medicine Clinical Practice Guidelines for Hemodynamic Support of Pediatric and Neonatal Septic Shock Executive Summary. Pediatr Crit Care Med. 2017. PMID:28723883 
  35. Extracorporeal Membrane Oxygenation for Severe Pediatric Respiratory Failure. Respir Care. 2017;62(6):732-750. PMID:28546375 
  36. The authors reply Pediatr Crit Care Med. 2017;18(5):501-502. doi:10.1097/PCC.0000000000001158  PMCID:PMC5506827  PMID:28475543 
  37. Tight Glycemic Control in Critically Ill Children NEJM. 2017;376(8):729-741. doi:10.1056/NEJMoa1612348  PMCID:PMC5444653  PMID:28118549 
  38. New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality. Pediatr Crit Care Med. 2017;18(1):8-16. PMID:28060151 
  39. High-Flow Oxygen as Noninvasive Ventilation May Complicate Timely Intubation in Patients With Acute Respiratory Distress Syndrome. Crit Care Med. 2016;44(8):e768-9. PMID:27428147 
  40. Functional outcomes for children with severe sepsis: is a "good save" good enough? Pediatr Crit Care Med. 2013;14(9):893-4. PMID:24226554 
  41. Relationship between hyperglycemia and outcome in children with severe traumatic brain injury. Pediatr Crit Care Med. 2012;13(1):85-91. doi:10.1097/PCC.0b013e3182192c30  PMCID:PMC3677026  PMID:21499170 
  42. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med. 2009;37(2):666-88. PMCID:PMC4447433  PMID:19325359 
  43. Hyperglycemia in pediatric critical illness: Does one size fit all? Pediatr Crit Care Med. 2007;8(6):585-6. PMID:17989565 
  44. Goal-directed management of pediatric shock in the emergency department Clin Ped Emerg Med. 2007;8(3):165-175. 
  45. Primary ocular posttransplant lymphoproliferative disease in pediatric liver transplant patients. J Pediatr Gastroenterol Nutr. 2001;32(1):89-91. PMID:11176333 
Last updated: 12/05/2022
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