Cynthia M. Ortinau, M.D.

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Assistant Professor of Pediatrics, Newborn Medicine
Newborn Medicine

phone: (314) 454-6148


  • BA, University of Missouri –Kansas City School of Arts and Sciences 2004
  • MD, University of Missouri - Kansas City School of Medicine2005
  • MSCI, Washington University in St. Louis2014


  • Pediatric Residency, St. Louis Children's Hospital2005 - 2008
  • Neonatal-Perinatal Medicine Fellowship, Washington University School of Medicine2008 - 2011
  • Effective Research Execution Course, Washington University in St. Louis2018 - 2018

Licensure and Board Certification

  • 2009Board Certified in Pediatrics, American Board of Pediatrics
  • 2012Board Certified in Neonatal-Perinatal Medicine, American Board of Pediatrics
  • 2016MO, Registered Medical Practioner, Missouri Board of Healing Arts

Honors and Awards

  • Travel Award – American Academy of Pediatrics2006
  • Travel Award – Pediatric Academic Societies2010
  • Washington University in St. Louis Department of Pediatrics Loan Repayment Award2011
  • Partners in Excellence Award, Team Leader, Brigham and Women's Hospital2014

Recent Publications view all (32)

Publication Co-Authors

  1. Optimizing Neurodevelopmental Outcomes in Neonates With Congenital Heart Disease. Pediatrics. 2022;150(Suppl 2). PMID:36317967 
  2. Quantification of sulcal emergence timing and its variability in early fetal life: Hemispheric asymmetry and sex difference. Neuroimage. 2022;263:119629. PMID:36115591 
  3. Trajectories of Maternal and Paternal Psychological Distress After Fetal Diagnosis of Moderate-Severe Congenital Heart Disease. J Pediatr Psychol. 2022. PMID:35976135 
  4. Placental Delayed Villous Maturation is Associated with Fetal Congenital Heart Disease. Am J Obstet Gynecol. 2022. PMID:35985515 
  5. Partnering With Stakeholders to Inform the Co-Design of a Psychosocial Intervention for Prenatally Diagnosed Congenital Heart Disease. J Patient Exp. 2022;9:23743735221092488. PMCID:PMC9039438  PMID:35493441 
  6. Brain charts for the human lifespan. Nature. 2022. PMID:35388223 
  7. Fetal Brain Volume Predicts Neurodevelopment in Congenital Heart Disease. Circulation. 2022. PMID:35143287 
  8. Proceedings of the 13th International Newborn Brain Conference: Neuro-imaging studies. J Neonatal Perinatal Med. 2022;15(2):389-409. PMID:35431184 
  9. Optimal Method for Fetal Brain Age Prediction Using Multiplanar Slices From Structural Magnetic Resonance Imaging. Front Neurosci. 2021;15:714252. PMCID:PMC8542770  PMID:34707474 
  10. Neonatal Brain Structure and Cognitively Stimulating Parenting Differentially Relate to Cognitive and Behavioral Outcomes of Children Born Very Preterm. Biol Psychiatry Glob Open Sci. 2021;1(2):87-89. PMCID:PMC9616377  PMID:36324996 
  11. Tractography of the Cerebellar Peduncles in Second- and Third-Trimester Fetuses. AJNR Am J Neuroradiol. 2021;42(1):194-200. PMCID:PMC7814802  PMID:33431505 
  12. A Deep Attentive Convolutional Neural Network for Automatic Cortical Plate Segmentation in Fetal MRI. IEEE Trans Med Imaging. 2020;PP. PMID:33351755 
  13. Fetal Cortical Plate Segmentation Using Fully Convolutional Networks With Multiple Plane Aggregation. Front Neurosci. 2020;14:591683. PMCID:PMC7738480  PMID:33343286 
  14. Regional Brain Growth Trajectories in Fetuses with Congenital Heart Disease. Ann Neurol. 2020. PMID:33084086 
  15. Association of Isolated Congenital Heart Disease with Fetal Brain Maturation. AJNR Am J Neuroradiol. 2020;41(8):1525-1531. PMID:32646947 
  16. In vivo characterization of emerging white matter microstructure in the fetal brain in the third trimester. Hum Brain Mapp. 2020. PMID:32374063 
  17. Temporal Patterns of Emergence and Spatial Distribution of Sulcal Pits During Fetal Life. Cereb Cortex. 2020. PMID:32219376 
  18. Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification. Neuroimage. 2019;188:473-482. PMID:30553042 
  19. Fetal brain growth portrayed by a spatiotemporal diffusion tensor MRI atlas computed from in utero images. Neuroimage. 2019;185:593-608. PMCID:PMC6289660  PMID:30172006 
  20. Early-Emerging Sulcal Patterns Are Atypical in Fetuses with Congenital Heart Disease. Cereb Cortex. 2018. PMCID:PMC6644862  PMID:30272144 
  21. Disorganized Patterns of Sulcal Position in Fetal Brains with Agenesis of Corpus Callosum. Cereb Cortex. 2018;28(9):3192-3203. PMCID:PMC6095213  PMID:30124828 
  22. Tract-Specific Group Analysis in Fetal Cohorts Using in utero Diffusion Tensor Imaging. Med Image Comput Comput Assist Interv. 2018;11072:28-35. PMCID:PMC7456441  PMID:32869014 
  23. Dynamic patterns of cortical expansion during folding of the preterm human brain. Proc Natl Acad Sci U S A. 2018;115(12):3156-3161. PMCID:PMC5866555  PMID:29507201 
  24. Intraventricular Hemorrhage in Moderate to Severe Congenital Heart Disease. Pediatr Crit Care Med. 2018;19(1):56-63. PMCID:PMC5777323  PMID:29210924 
  25. Prenatal to postnatal trajectory of brain growth in complex congenital heart disease. Neuroimage Clin. 2018;20:913-922. PMCID:PMC6178192  PMID:30308377 
  26. The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy. J Pediatr. 2017;187:26-33.e1. PMCID:PMC5533615  PMID:28479101 
  27. Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities. AJNR Am J Neuroradiol. 2017;38(7):1449-1455. PMCID:PMC5509490  PMID:28522661 
  28. A normative spatiotemporal MRI atlas of the fetal brain for automatic segmentation and analysis of early brain growth. Sci Rep. 2017;7(1):476. PMCID:PMC5428658  PMID:28352082 
  29. Diffusion tractography and neuromotor outcome in very preterm children with white matter abnormalities. Pediatr Res. 2014;76(1):86-92. PMCID:PMC4062577  PMID:24713814 
  30. Cortical folding is altered before surgery in infants with congenital heart disease. J Pediatr. 2013;163(5):1507-10. PMCID:PMC3905308  PMID:23988135 
  31. Congenital heart disease affects cerebral size but not brain growth. Pediatr Cardiol. 2012;33(7):1138-46. PMCID:PMC3702162  PMID:22450354 
  32. Regional alterations in cerebral growth exist preoperatively in infants with congenital heart disease. J Thorac Cardiovasc Surg. 2012;143(6):1264-70. doi:10.1016/j.jtcvs.2011.10.039  PMCID:PMC3322305  PMID:22143100 
Last updated: 11/07/2022
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