Bednarski Lab

Unraveling the molecular signals behind blood cell development our lab studies mechanisms regulating early hematopoiesis and B cell lymphopoiesis with a focus on how DNA damage signals activate programs that promote normal differentiation and suppress leukemogenesis. We investigate transcriptional responses to DNA breaks during antigen receptor assembly and explore how these pathways are disrupted in leukemia and primary immune deficiencies to guide strategies for prevention and treatment.