Bigley Lab

Uncovering the viral roots of autoimmune disease to advance understanding and treatment, our lab investigates how infections disrupt immune regulation and trigger chronic conditions. By studying roseolovirus and other thymus-targeting viruses, we aim to reveal mechanisms that lead to loss of immune tolerance, autoreactive cell development and lifelong predisposition to autoimmunity. Using advanced immunologic and molecular virology tools, we strive to identify therapeutic targets and strategies that improve outcomes for millions affected by autoimmune disorders.