Dickson Lab

Advancing therapies for MPS disorders, the Dickson Laboratory investigates lysosomal enzyme deficiencies that disrupt glycosaminoglycan metabolism and lead to severe neurological complications. Focused on cerebrospinal fluid delivery of recombinant enzymes, our research demonstrates widespread biodistribution and correction of lysosomal storage in MPS models. By integrating neuroimaging, neuropathology and immune response studies, we bridge bench-to-bedside efforts that include clinical trials aimed at transforming outcomes for patients with these devastating conditions.