Halabi Lab

Exploring mechanisms and differences in artery development in the context of extracellular matrix gene mutations our lab studies how vascular elastic fibers form and how defects in this process lead to diseases such as aneurysms and hypertension. Using models with fibulin-4 mutations we investigate why large arteries show fragmented fibers while small arteries remain intact, aiming to uncover how these differences contribute to aneurysm development.