Horani Lab

Investigating genetic impacts on cilia function to combat airway diseases, our laboratory examines how mutations disrupt the biology of airway and motile cilia, impairing mucociliary clearance and driving conditions such as primary ciliary dyskinesia, asthma and COPD. Using primary human and mouse cell cultures with advanced genetic manipulation, we study airway epithelial differentiation and ciliogenesis to uncover the roles of novel proteins and develop strategies to restore cilia function and protect respiratory health.