Joshua B. Rubin Lab

Combining basic science and clinical research to advance brain tumor treatment, the Rubin Lab is dedicated to uncovering the mechanisms of tumorigenesis and therapy resistance in malignant brain cancers. Our work explores how factors such as epigenetics, signaling pathways, metabolism and cellular senescence influence disease progression, with a special focus on sex-specific differences in cancer risk and survival. By translating these insights into targeted strategies, we aim to develop more effective therapies and improve outcomes for diverse patient populations.