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Supporting faculty through the promotion process we provide guidance and resources to help individuals meet professional milestones in research, education and clinical care. Our goal is to ensure transparency and foster success across the WashU Medicine community.

Providing expert care for children with rheumatic and immune disorders our team delivers comprehensive evaluations and treatment across four specialty clinics and inpatient services. With more than 4,000 visits annually and access to advanced diagnostic testing, we combine multidisciplinary expertise with collaborative care to manage complex conditions.

Pediatric Clinical Immunology Program • Clinics

Providing comprehensive evaluation and treatment for children with rheumatologic disorders and immunodeficiencies, we combine compassionate care with access to innovative clinical research. Our team is committed to advancing therapies, fostering collaboration and training future leaders through rigorous fellowship programs.

Providing an intensive introduction to clinical rheumatology, this three-year ACGME-accredited program offers a first year focused on comprehensive clinical training, followed by two years that allow fellows to concentrate primarily on research.

Fighting multidrug-resistant Klebsiella pneumoniae our lab investigates the pathogenesis of this urgent CDC and WHO priority pathogen and works toward vaccine development. We study classical and hypervirulent strains using mouse models of pneumonia and urinary tract infection to understand virulence factors including capsular types, O-antigens and the fimK regulatory gene. With over 300 clinical isolates in our repository we aim to identify strategies that inhibit virulence or prevent infection through effective vaccines.

Research profile

Unveiling ERp29's crucial role in correcting biogenesis defects, our laboratory investigates how small molecules enhance the function of mutant proteins that disrupt normal protein folding and trafficking. Building on discoveries in cystic fibrosis ion channel biology, we now explore broader mechanisms of protein biogenesis regulation across diverse inherited diseases, aiming to identify therapeutic strategies that restore cellular balance.

Research profile

Exploring the molecular signals behind liver regeneration, our laboratory investigates how this remarkable organ restores both structure and function after injury or disease. Using rodent partial hepatectomy and complementary models, we focus on extrahepatic factors that regulate liver mass and regenerative capacity. Translating these insights to human liver disorders, we have identified a novel metabolomic marker with potential to predict clinical outcomes in pediatric acute liver failure, bridging fundamental research with real-world impact.

Research profile

Enhancing pediatric critical care through predictive models and decision support tools, our team specializes in translational biomedical informatics to transform high-resolution EHR data into actionable insights. By developing machine learning-driven solutions that integrate seamlessly into clinical workflows, we aim to improve decision-making at the bedside and advance personalized care for critically ill children.

Research profile

Studying how cells regulate metabolic programs and their link to neurological disease our lab uses genetics, cell biology and systems biology to uncover how dysfunction in these networks drives neurodegeneration. Our ultimate goal is to translate this knowledge into therapeutic strategies for disorders of the nervous system.

Research profile

Exploring inflammation's role in blood cancer and optimizing treatment our lab studies how inflammatory signals affect hematopoietic stem cells and contribute to malignancies. While inflammation is essential for immune defense prolonged exposure can impair stem cell function and drive clonal expansion of mutant cells leading to blood cancers. By understanding these responses we aim to improve stem cell health and develop strategies to prevent hematopoietic malignancies.

Research profile