Pediatric Cardiovascular and Pulmonary Research Training Program

Award #: T32 HL125241

Project periodFebruary 2015 – February 2025
Predoc slots2
Postdoc slots4

This training program is designed to attract and train both predoctoral and postdoctoral investigators in basic investigation of childhood diseases related to cardiovascular and pulmonary biology. The need for a training program in the cellular/molecular basis of cardiovascular and pulmonary disease, especially of physician-scientists interested in childhood diseases, is based upon clear evidence of a small, national pool of such individuals as faculty or trainees.

Our program is designed to address this need from two important perspectives

  • to allow pediatric and other clinical fellows, with an interest in basic research, to develop research competence and career training;
  • to attract and train talented basic scientists to study mechanisms related to childhood diseases.

In addition to continuing our strong training in developmental/cell biology and the molecular basis of disease, our program takes advantage of institutional strengths in genetics, stem cell biology, genomics, and bioinformatics—all of which are components of the foundation of modern research. We have adopted a training curriculum for four postdoctoral and two predoctoral fellows with an uninterrupted two to three year block of full-time investigation. This is combined with an integrated and multidisciplinary set of didactic seminars, journal clubs, and formal courses that are selected by the trainee in consultation with the mentor/program administrators to provide individualized education in key aspects of cardiopulmonary development and disease.

Our objectives are:

  • to provide extensive mentoring to the trainee for career development and for developing independent research plans that focus on pediatric diseases;
  • to promote training in basic cell and molecular biology, genomics, and bioinformatics together with clinical translational research;
  • to guide the trainees’ development so that, after the completion of training, successful competition for independent funding is likely.

Principal Investigators/Program Directors

Robert P. Mecham, PhD

Alumni Endowed Professor of Cell Biology and Physiology

Juliane Bubeck-Wardenburg, MD, PhD

Donald B. Strominger, MD Professor of Pediatrics, Critical Care Medicine
Division Director, Critical Care Medicine
Researcher, Pediatric Research


Program FacultyDepartment or InstitutionRole in Program
Blumer, KendallCell Biology and PhysiologyMentor
Byers, DerekInternal Medicine / Pulmonary and Critical CareMentor
Choi, KyungheePathology and ImmunologyMentor
Cole, F. SessionsPediatrics / Newborn MedicineMentor / Executive Committee
Crawford, PeterMedicine / Cardiology (Genetics)Mentor
Druley, ToddPediatrics (Genetics)Mentor
Dutcher, SusanGenetics (Cell Biology and Physiology)Mentor
Holtzman, MichaelInternal Medicine / PulmonaryMentor
Hruska, KeithPediatrics / NephrologyMentor
Jay, PatrickPediatrics / CardiologyMentor
Kozel, BethPediatrics / GeneticsMentor
Mecham, RobertCell Biology and PhysiologyProgram Director / Mentor
Milbrant, JeffreyGeneticsMentor
Nagarajan, RakeshPathology & ImmunologyMentor
Nerbonne, JeanneDevelopmental BiologyMentor / Executive Committee
Nichols, ColinCell Biology and PhysiologyMentor
Ornitz, DavidDevelopmental BiologyMentor / Executive Committee
Province, MichaelGeneticsMentor
Rentschler, StaceyInternal Medicine / CardiovascularMentor
Solnica-Krezek, LiliannaDevelopmental BiologyMentor
Wilson, DavidPediatrics / Hematology and OncologyMentor
Yoo, AndrewDevelopmental BiologyMentor