Rosen Lab

Fighting multidrug-resistant Klebsiella pneumoniae our lab investigates the pathogenesis of this urgent CDC and WHO priority pathogen and works toward vaccine development. We study classical and hypervirulent strains using mouse models of pneumonia and urinary tract infection to understand virulence factors including capsular types, O-antigens and the fimK regulatory gene. With over 300 clinical isolates in our repository we aim to identify strategies that inhibit virulence or prevent infection through effective vaccines.