Stone Lab

Decoding insulin resistance through rare genetic syndromes, our laboratory investigates severe insulin resistance disorders as unique experiments of nature to uncover fundamental principles of insulin signaling. Leveraging patient-derived models and CRISPR/Cas9 gene editing, we create transgenic mice and induced pluripotent stem cells differentiated into key cell types, enabling deep insights into molecular pathology and therapeutic discovery. These approaches bridge basic biology with translational strategies to improve care for metabolic disease.