Labs by division

Illuminating the functional impact of genetic variants, our laboratory explores the genetic basis of rare Mendelian disorders while pioneering high-throughput cell-based assays and functional genomics techniques to characterize clinically observed variants. Combining genome sequencing with advanced informatics, we strive to make genetic data more actionable at the bedside, improving diagnostic precision and patient care.

Research profile

Unraveling the molecular signals behind blood cell development our lab studies mechanisms regulating early hematopoiesis and B cell lymphopoiesis with a focus on how DNA damage signals activate programs that promote normal differentiation and suppress leukemogenesis. We investigate transcriptional responses to DNA breaks during antigen receptor assembly and explore how these pathways are disrupted in leukemia and primary immune deficiencies to guide strategies for prevention and treatment.

Research profile

Uncovering the viral roots of autoimmune disease to advance understanding and treatment, our lab investigates how infections disrupt immune regulation and trigger chronic conditions. By studying roseolovirus and other thymus-targeting viruses, we aim to reveal mechanisms that lead to loss of immune tolerance, autoreactive cell development and lifelong predisposition to autoimmunity. Using advanced immunologic and molecular virology tools, we strive to identify therapeutic targets and strategies that improve outcomes for millions affected by autoimmune disorders.

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Exploring genetic, environmental and developmental influences on glioma formation and cognitive impairment, our lab investigates how these factors shape risk in patients with Neurofibromatosis Type 1 and the broader pediatric population. Using murine models as a platform, we aim to uncover mechanisms driving tumor development and neurodevelopmental changes, identify new strategies for patient risk assessment and discover therapeutic targets. Through this work, we strive to transform understanding and improve outcomes for children affected by NF1 and related conditions.

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Driving innovative approaches to combat infectious diseases by advancing the understanding of host-pathogen interactions, our lab is dedicated to uncovering how bacteria interact with the host, evade immune defenses and develop antibiotic resistance. Through an interdisciplinary team blending molecular microbiology, immunology and genetic analysis, we aim to identify new therapeutic targets and strategies that address some of the most pressing global health challenges.

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Unlocking pathways to improve brain health in children with congenital heart disease, our lab uses advanced MRI techniques to study brain development, injury and neurodevelopmental outcomes. Congenital heart disease — the most common birth defect — is linked to high rates of cognitive and behavioral challenges that begin prenatally. By investigating brain dysmaturation in relation to cardiac physiology, prenatal environment and social factors, we aim to identify targeted neuroprotective strategies that enhance outcomes throughout childhood and beyond.

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Improving outcomes for children with chronic illnesses through research and education, the Child Health and Education Lab focuses on conditions such as Sickle Cell Disease and brain tumors. Led by Allison King, MD, MPH, PhD, our team investigates how environmental, cognitive and psychosocial factors influence health and development. Through partnerships like the Heartland and Southwest Sickle Cell Disease Network, we work to enhance care and quality of life across an eight-state region, while advancing strategies for assessment, transition and long-term support.

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Exploring molecular mechanisms of neutrophil activation, our laboratory investigates how these critical immune cells shape host defense and influence health and disease. Focusing on the consequences of neutrophil dysregulation, we study its role in driving severe inflammation and contributing to pathology in conditions such as sepsis, organ transplant, acute lung injury and stroke, with the goal of identifying strategies to restore balance and improve patient outcomes.

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Investigating the origins of immune-mediated disorders in children, the Cooper lab focuses on uncovering genetic mechanisms that contribute to pediatric immune dysregulation. Using advanced genomic sequencing, we identify genetic causes of disease and employ both in vitro and in vivo models to deepen understanding of these conditions. Our work emphasizes leveraging cutting-edge sequencing technologies to reveal mechanisms underlying undiagnosed immune deficiencies in children.

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Discovering genetic and biological determinants of bleeding and thrombosis our lab combines expertise in genomics, bioinformatics and molecular biology to uncover mechanisms underlying disorders such as von Willebrand disease and platelet dysfunction. We develop interactive genomic databases, investigate mutations like NBEAL2 and ETV6 and use CRISPR-modified mice to study hemostasis. Our goal is to translate these insights into novel therapies that improve quality of life for patients with bleeding and thrombotic disorders.

Research profile