Allergy & Pulmonary Medicine

Research profile

Investigating genetic impacts on cilia function to combat airway diseases, our laboratory examines how mutations disrupt the biology of airway and motile cilia, impairing mucociliary clearance and driving conditions such as primary ciliary dyskinesia, asthma and COPD. Using primary human and mouse cell cultures with advanced genetic manipulation, we study airway epithelial differentiation and ciliogenesis to uncover the roles of novel proteins and develop strategies to restore cilia function and protect respiratory health.

Research profile

Exploring mechanisms of lung disease and identifying non-CFTR modifiers that influence severity, our lab focuses on airway disorders such as cystic fibrosis to uncover biological pathways driving disease progression. Using molecular biology, genetics, biochemistry and bioinformatics, we investigate factors beyond CFTR that shape inflammatory and immune responses in airway epithelia. Through genomics, multi-omics analyses and translational research, we aim to develop innovative therapeutic targets and personalized strategies to improve outcomes for people with CF and related conditions.

Research profile

Unveiling ERp29's crucial role in correcting biogenesis defects, our laboratory investigates how small molecules enhance the function of mutant proteins that disrupt normal protein folding and trafficking. Building on discoveries in cystic fibrosis ion channel biology, we now explore broader mechanisms of protein biogenesis regulation across diverse inherited diseases, aiming to identify therapeutic strategies that restore cellular balance.

Research profile