Nephrology, Hypertension & Pheresis

Exploring mechanisms and differences in artery development in the context of extracellular matrix gene mutations our lab studies how vascular elastic fibers form and how defects in this process lead to diseases such as aneurysms and hypertension. Using models with fibulin-4 mutations we investigate why large arteries show fragmented fibers while small arteries remain intact, aiming to uncover how these differences contribute to aneurysm development.

Research profile

Exploring the causes and cardiovascular impacts of CKD-MBD our lab focuses on uncovering the mechanisms behind chronic kidney disease-mineral and bone disorder. Kidney disease leads to complications throughout the body many of which influence mortality rates. Rather than the kidney disease itself most deaths occur due to associated cardiovascular issues. The risk of cardiovascular disease in chronic kidney disease is shaped by unique factors related to CKD-MBD and understanding these relationships is central to our research.

Research profile