Newborn Medicine

We are a multi-PI lab with a primary interest in understanding the role of serpins (serine proteinase inhibitors) in normal physiology and disease. Serpins play important roles in maintaining cellular homeostasis by regulating the activity of their target proteases. As such, an imbalance in the protease-serpin equilibrium can lead to cellular dysfunction, tissue damage and death.

Luke research profile
Pak research profile
Silverman research profile

Our lab is interested in understanding the genetic causes of rare diseases and birth defects among infants and children. Our research goals are to use genomic sequencing technologies including whole exome and genome sequencing, RNASeq and gene expression studies to identify the genetic causes of rare diseases and birth defects among infants and children and to use functional studies to determine the disease mechanisms underlying these rare diseases.

Wambach research profile
Cole research profile