Labs by division

Investigating how hormonal changes during pregnancy shape long-term cardiovascular health, our center explores the molecular mechanisms linking gestational hyperandrogenism and exposure to endocrine-disrupting chemicals with adverse maternal and fetal cardio-metabolic outcomes. By integrating large animal models with cellular and molecular biology, we aim to uncover pathways that predispose offspring to cardiovascular disease and identify strategies for prevention and treatment. Our work advances the developmental origins of health and disease framework, driving innovation in early-life interventions.

Research profile

Decoding the genetic causes of rare childhood diseases through cutting-edge genomics, our lab is committed to uncovering the molecular basis of severe conditions and birth defects in infants and children. Using advanced sequencing technologies such as whole exome and genome sequencing, RNASeq and gene expression profiling, we identify pathogenic variants and investigate their functional impact. Our focus on disorders of pulmonary surfactant metabolism, including genes like SFTPB, SFTPC, ABCA3 and NKX2-1, aims to reveal new therapeutic targets and improve outcomes for children facing life-threatening respiratory diseases.

Wambach research profile
Cole research profile

Driving innovation in large-scale genomics, Todd Wylie brings over two decades of expertise in biology, informatics and analytics to advance genomic research and technology development. From contributing to the first human genome sequence to pioneering tools like ViroCap, Wylie has led efforts spanning cancer genomics, microbial analysis and high-throughput sequencing. His work bridges wet lab and computational science, delivering transformative solutions that enhance diagnostics and expand the frontiers of genomic medicine.

Research profile

Investigating maternal-microbe dynamics our lab studies how the vaginal microbiome and maternal immune response interact to influence reproductive outcomes. Through longitudinal analysis of pregnancy samples and in vitro and in vivo models we aim to uncover mechanisms linking microbial changes and viral infections to preterm birth, ultimately identifying biomarkers for better prediction and prevention.

Research profile

Advancing understanding of dietary fat digestion, this research focuses on the molecular mechanisms by which pancreatic lipases process fats in young children to support healthy growth and development. Complementary studies examine proteotoxicity in chronic pancreatitis, using misfolded mutant pancreatic lipases as a model to identify pathways that could lead to novel therapeutic strategies.

Research profile