Research

New treatment target ID’d for radiation-resistant cervical cancer

Two new studies from Washington University School of Medicine in St. Louis have identified a previously unrecognized pathway of cell death — named lysoptosis — and demonstrate how it could lead to new therapies for cervical cancer. Pictured is a human cervical cancer cell that is undergoing lysoptosis triggered by radiation. The cell is missing a key gene that protects against this type of cell death, making the cell easier to kill with radiation and chemotherapy. Lysosomes are shown in red. The cell nucleus is in blue.
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Understanding how cells die is key to developing new treatments for many diseases, whether the goal is to make cancer cells die or keep healthy cells alive in the face of other illnesses, such as massive infections or strokes. Two new studies from Washington University School of Medicine in St. Louis have identified a previously unrecognized pathway of cell death — named lysoptosis — and demonstrate how it could lead to new therapies for cervical cancer.