Paul W. Hruz, MD, PhD

The research efforts of Paul Hruz. MD, PhD, are directed toward understanding facilitative glucose transport as it relates to normal and disordered glucose homeostasis.  A primary effort in our laboratory is the determination of structure/function relationships within the facilitative glucose transport proteins (GLUTs). This is aiding efforts to identity isoform-selective small molecule transporter antagonists for glucose-dependent diseases. A primary focus is the development of novel drugs to treat non-alcoholic fatty liver disease, which now affects nearly half of all patients with type 2 diabetes. This is being pursued with the aid of state-of-the-art chemical and biophysical approaches.