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Unraveling the mechanisms of glucose transport, our laboratory investigates how facilitative glucose transporters regulate normal and disordered glucose homeostasis. Focusing on structure–function relationships within GLUT proteins, we apply advanced chemical and biophysical techniques to define the architecture of GLUT1 and GLUT4. In parallel, we examine how HIV protease inhibitors alter GLUT function, aiming to uncover molecular pathways that contribute to insulin resistance in treated patients.

Research profile

Exploring molecular pathogenesis and sex differences in pyelonephritis, our lab investigates interactions between pathogenic Gram-negative bacteria and their hosts using urinary tract infections as a primary model. We aim to understand host-pathogen dynamics in the urinary tract, how uropathogenic bacteria modulate immune responses and the role of sex in UTI pathogenesis.

Research profile

Providing expert care for complex infections in children our team offers full-time consultation at St. Louis Children’s Hospital for diagnosis and management of rare or difficult-to-treat conditions, including HIV/AIDS. With more than 800 inpatient consultations annually and outreach through community clinics, we combine advanced expertise with compassionate care.

Project A.R.K. (AIDS/HIV Resources and Knowledge) • Specialized Services

Combining expert clinical care with groundbreaking research, we diagnose and treat childhood infections while leading efforts to prevent disease and improve outcomes. Our team is dedicated to training future specialists and fostering innovation through collaborative studies in microbiology, immunology and infectious diseases.

Offering a broad and deep clinical experience along with a strong foundation in basic or clinical investigation, this three-year ACGME-accredited program features a flexible structure tailored to each fellow’s interests and prior experience.

Advancing clinical and translational research, the ICTS is dedicated to turning scientific discoveries into real-world health solutions. Through funding programs, training opportunities, data and recruitment services and community partnerships, ICTS provides the resources and expertise researchers need to accelerate innovation and improve health outcomes locally and globally.

Advancing careers in academic medicine, the Pediatric Research Pathway offers specialized training for physician-scientists during residency. Approved by the American Board of Pediatrics, this pathway is designed for MD/PhD graduates or those with equivalent research experience and commitment. Participants continue their research alongside clinical training and are encouraged to apply before or early in their PL-1 year.

Advancing research and care for individuals with intellectual and developmental disabilities, the WashU Medicine IDDRC, in collaboration with St. Louis Children’s Hospital, is part of a national network of 15 centers funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Established through an act of Congress in 1963, these centers unite leading universities and children’s hospitals to drive discovery, prevention and treatment strategies that improve lives and foster inclusion.