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Advancing research at the intersection of metabolism and immune function, our center focuses on musculoskeletal, kidney and gastrointestinal disorders, including microbiome-related conditions and diseases driven by metabolic and immune dysregulation. Through collaborative science and innovative approaches, we aim to uncover mechanisms that shape health and disease, translating discoveries into strategies that improve patient outcomes and quality of life.

Uncovering the molecular roots of immune disorders to improve care, the WashU Medicine Center for Pediatric Immunology is dedicated to advancing outcomes for children with inborn errors of immunity. By providing robust scientific infrastructure and leveraging cutting-edge technologies, the center drives discovery of genetic mechanisms that inform diagnosis and therapy. Through collaboration among clinicians, scientists and trainees, we aim to transform understanding and treatment of pediatric immune diseases.

Investigating the mechanisms behind childhood respiratory illnesses to improve health and well-being, our center is dedicated to reducing the global burden of pulmonary diseases such as pneumonia and asthma. By advancing research through innovative protocols and translating discoveries into clinical care, we aim to enhance diagnostics, develop effective treatments and ultimately save lives. Through collaboration and cutting-edge science, we strive to create a healthier future for children everywhere.

Bringing together researchers and patient communities to accelerate breakthroughs, our center fosters collaboration in rare and genetic disease research. By uniting WashU Medicine experts with individuals affected by rare conditions, we create a dynamic network that drives innovation and speeds the path to new therapies. Through shared knowledge and resources, we aim to transform understanding and treatment, ultimately improving lives.

Providing comprehensive training in child abuse pediatrics, this three-year ACGME-accredited fellowship leverages the clinical resources of the nationally renowned St. Louis Children’s Hospital and the academic and research opportunities offered by WashU Medicine.

Driving impact through programs and partnerships, Child Care Aware® of Missouri supports families and providers with workforce development, business resources, advocacy and policy initiatives. Through efforts like Child Care Keeps Missouri Working℠, the organization helps businesses address recruitment and retention challenges caused by limited access to quality child care.

Improving outcomes for children with chronic illnesses through research and education, the Child Health and Education Lab focuses on conditions such as Sickle Cell Disease and brain tumors. Led by Allison King, MD, MPH, PhD, our team investigates how environmental, cognitive and psychosocial factors influence health and development. Through partnerships like the Heartland and Southwest Sickle Cell Disease Network, we work to enhance care and quality of life across an eight-state region, while advancing strategies for assessment, transition and long-term support.

Research profile

Accelerating the pace of discovery, the Children’s Discovery Institute (CDI) represents a transformative partnership between St. Louis Children’s Hospital and WashU Medicine, dedicated to redefining pediatric research and delivering innovative therapies for previously untreatable conditions. Through expanded donor-funded initiatives in gene and cell-based therapies, infectious disease and pediatric immunology, CDI fosters collaboration across disciplines to drive faster scientific breakthroughs and improve outcomes for children everywhere.

Exploring molecular mechanisms of neutrophil activation, our laboratory investigates how these critical immune cells shape host defense and influence health and disease. Focusing on the consequences of neutrophil dysregulation, we study its role in driving severe inflammation and contributing to pathology in conditions such as sepsis, organ transplant, acute lung injury and stroke, with the goal of identifying strategies to restore balance and improve patient outcomes.

Research profile

Offering a pathway to leadership in health informatics, the Institute for Informatics, Data Science and Biostatistics, together with the Department of Pediatrics, is pleased to present the Clinical Informatics Fellowship. As one of the newest subspecialties recognized by the American Board of Medical Specialties, clinical informatics focuses on biomedical data, computational systems and clinical process improvement applied to medical practice. The program’s mission is to develop leaders who will advance the field of health informatics.