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Uncovering the viral roots of autoimmune disease to advance understanding and treatment, our lab investigates how infections disrupt immune regulation and trigger chronic conditions. By studying roseolovirus and other thymus-targeting viruses, we aim to reveal mechanisms that lead to loss of immune tolerance, autoreactive cell development and lifelong predisposition to autoimmunity. Using advanced immunologic and molecular virology tools, we strive to identify therapeutic targets and strategies that improve outcomes for millions affected by autoimmune disorders.

Research profile

The Steven & Susan Lipstein BJC Institute of Health (BJCIH) at WashU Medicine is an 11-story, 680,000-square-foot research facility that opened in 2009 as the university’s largest building. Supported by a $30 million naming gift from BJC HealthCare, the $235 million institute houses advanced laboratories and research support spaces and earned LEED Gold certification for its sustainable design. In 2021, Washington University announced a six-floor expansion adding 160,000 square feet of state-of-the-art lab space, including a high-containment BSL-3 laboratory for research on dangerous pathogens. The building faces the Ellen S. Clark Hope Plaza, a serene space designed by artist Maya Lin to honor Ellen Clark.

Shared spaces

An LGBTQA affinity group for Washington University in St. Louis faculty and staff. BRIDGE: Bravery, Responsibility, Inclusion, Dignity, Guidance, and Empowerment.

Exploring genetic, environmental and developmental influences on glioma formation and cognitive impairment, our lab investigates how these factors shape risk in patients with Neurofibromatosis Type 1 and the broader pediatric population. Using murine models as a platform, we aim to uncover mechanisms driving tumor development and neurodevelopmental changes, identify new strategies for patient risk assessment and discover therapeutic targets. Through this work, we strive to transform understanding and improve outcomes for children affected by NF1 and related conditions.

Research profile

Driving innovative approaches to combat infectious diseases by advancing the understanding of host-pathogen interactions, our lab is dedicated to uncovering how bacteria interact with the host, evade immune defenses and develop antibiotic resistance. Through an interdisciplinary team blending molecular microbiology, immunology and genetic analysis, we aim to identify new therapeutic targets and strategies that address some of the most pressing global health challenges.

Research profile

Drawing on decades of experience and innovation, we provide comprehensive diagnostic and therapeutic services for children with heart disease and adults with congenital heart conditions. Our team combines advanced clinical care with groundbreaking research and specialized training to improve outcomes and support families through every stage of care.

Delivering advanced heart care with compassion and expertise our team at St. Louis Children’s Hospital provides comprehensive services for infants and children with heart conditions. From diagnostic evaluations to complex interventions, we combine leading-edge treatments with a commitment to supporting families throughout their care experience.

Pediatric Aortopathy Clinic • Heart Station

Preparing fellows to become skilled pediatric cardiologists, this ACGME-accredited program trains physicians to independently supervise the diagnosis and care of infants, children and young adults with all forms of congenital and acquired cardiac disease. Most fellows complete two years of clinical rotations followed by one year dedicated to research and electives. The program offers three positions annually.

The Center for Advanced Medicine serves as the outpatient clinic for many adult specialties at WashU Medicine. Patients receive multidisciplinary consultations, diagnostic services, medical treatments, same-day surgeries and other support — all in one convenient location.

This building is home to the Alvin J. Siteman Cancer Center, an internationally recognized leader in cancer treatment, research, prevention, education and community outreach. Siteman is the only cancer center in Missouri — and within a 240-mile radius of St. Louis — to hold the Comprehensive Cancer Center designation from the National Cancer Institute and membership in the National Comprehensive Cancer Network.

The center brings together the expertise of more than 350 WashU Medicine physicians and research scientists, caring for over 7,000 newly diagnosed cancer patients and 32,000 follow-up patients each year. These specialists collectively manage nearly $150 million in cancer research and training grants, driving innovation and advancing cancer care.

Facilitating top-quality clinical research, this center supports WashU Medicine investigators with comprehensive administrative and clinical research services from initial proposal development through study close-out. Our mission is to streamline processes, ensure regulatory compliance and provide expert guidance, enabling researchers to focus on advancing discoveries that improve patient care.