Labs by division

Our laboratory is interested in elucidating the molecular signaling mechanisms of liver regeneration. In addition to liver mass being precisely regulated in proportion to body mass, this organ is also able to regenerate the anatomic and functional deficits incurred by many forms of injury or disease (e.g. toxin exposure, trauma, infection). We use rodent partial hepatectomy and other models to investigate the mechanisms responsible for this remarkable regenerative potential, and have focused our recent efforts on defining and investigating the functional relevance of extrahepatic signals that influence regulation of liver mass and regeneration. In addition, we began a translational line of investigation in which lessons learned about liver regeneration in this basic model are applied to analyses of human liver diseases. Such studies led us to identify a novel metabolomic marker of liver regeneration and evaluate its utility in predicting clinical outcomes in pediatric acute liver failure.

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Our lab specializes in translational biomedical informatics, leveraging high-resolution electronic health record (EHR) data to develop machine learning-based, clinically applicable decision support tools.

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The laboratory uses genetics, cell biology, and systems biology approaches to study how the cell regulates its metabolic programs and how dysfunctions in these programs lead to neurological disease. Our ultimate goal is to translate knowledge of these regulatory networks into therapeutic approaches for neurodegenerative disorders.

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The Schuettpelz Lab is interested in understanding how inflammatory signals regulate hematopoietic stem cells (HSC). In particular, we are studying the role of toll-like receptor (TLR) signaling in HSCs. Our lab is currently using mouse models to better define the role of individual TLRs in regulating HSC function. In addition, we are exploring the connection between enhanced TLR signaling and myelodysplastic syndrome (MDS) through the use of various mouse models of this disease.

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Our laboratory focuses on the cell and molecular biology of intracellular protein targeting and degradation.

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Our goal is to deliver personalized gut microbiome-based risk assessment and antibiotic stewardship for pediatric sepsis.

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My academic focus is on the development of safer less toxic methods of hematopoietic stem cell transplantation in children. Toward this, I am investigating reduced intensity transplantation for children with hemoglobinopathy (sickle cell disease and thalassemia) using the best available related or alternate donors.

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Shinawi’s special interests are in genomics and genomic disorders, cytogenetic abnormalities, microarray technology, skeletal dysplasia, the genetic basis of autism and metabolic conditions. He is using reverse genomics to characterize the phenotypes of genomic disorders with special focus on 16p11.2 rearrangements. He is working to develop novel methods for detection of metabolic conditions. Shinawi is co-director of the Women and Infants’ Health Specimen Consortium (WIHSC) and is investigating metabolomics and feto-maternal interaction during pregnancy.

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Our lab investigates the host response to pathogenic infections, specifically the mechanisms underlying antiviral innate immune responses.  We are also focused on the role of the microbiota in the establishment and maintenance of antiviral immunity.

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The goal of the Stone lab is to promote concepts of precision medicine, technology, and design to the care of individuals suffering from complex endocrine conditions including diabetes, insulin resistance, and obesity. By studying unique individuals, we hope to gain insights into the underlying mechanisms of disease. We hope to translate this information into new treatments for diabetes, obesity, and insulin resistance.

Research profile