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Decoding insulin resistance through rare genetic syndromes, our laboratory investigates severe insulin resistance disorders as unique experiments of nature to uncover fundamental principles of insulin signaling. Leveraging patient-derived models and CRISPR/Cas9 gene editing, we create transgenic mice and induced pluripotent stem cells differentiated into key cell types, enabling deep insights into molecular pathology and therapeutic discovery. These approaches bridge basic biology with translational strategies to improve care for metabolic disease.

Research profile

Advancing molecular diagnosis of infectious diseases our lab develops tests to detect a wide range of pathogens including all known human herpes viruses, polyoma viruses JC and BK, parvovirus B19, enteroviruses, HIV, Toxoplasma gondii, Bordetella pertussis and parapertussis, Ehrlichia, Rickettsia, Bartonella, Leptospira, Borrelia, Mycoplasma pneumoniae and Chlamydia pneumoniae. We specialize in quantitative assays for CMV, EBV, HHV-6 and BK virus and have implemented commercial tests for HIV RNA, hepatitis C RNA, hepatitis C genotyping and hepatitis B DNA. Our work also includes detecting antiviral resistance in CMV and hepatitis B virus and identifying bacterial antibiotic resistance such as methicillin, fluoroquinolone and macrolide resistance.

Research profile

Serving as the hub for campus recreation, the Gary M. Sumers Recreation Center offers state-of-the-art facilities and programs that engage the university community. With cardio and strength equipment, an indoor pool, fitness studios, courts for multiple sports and wellness amenities like the Zen Den, Sumers Rec provides resources to support health, balance and connection.

Defining molecular features driving leukemogenesis to improve outcomes in acute leukemia our lab investigates pathways that differ between malignant and healthy cells, promote chemotherapy resistance and support leukemia stem cell biology. Current projects focus on intracellular metabolism including amino acid and nucleotide metabolism, cellular energetics and polyunsaturated fatty acid metabolism, the unfolded protein response and its role in stress adaptation and mitochondrial regulation critical for cancer cell survival. We also examine how these mechanisms influence healthy hematopoietic stem and progenitor cells to guide rational therapeutic strategies.

Research profile

Exploring how gut microbiota shape disease outcomes, this laboratory investigates microbial influences on pediatric health through genomic sequencing, clinical data and collaborative research. With a focus on gastrointestinal diseases such as necrotizing enterocolitis, projects integrate metagenomics, cohort studies and phylogenetic analysis to uncover microbial drivers of disease and inform future therapeutic strategies.

Research profile

Investigating how pharmacological agents reshape cellular behavior in health and disease, the Taylor Lab at WashU Medicine studies the mechanisms that drive normal and malignant hematopoiesis to improve treatment outcomes for children with cancer. Childhood leukemia arises when genetic mutations disrupt normal blood cell formation and convert healthy cells into cancerous ones, yet major questions remain about how these mutations hijack cellular machinery to sustain disease. Transcription factors — molecular switches that control gene expression — play a central role in this process. In healthy blood development, they guide the programs that determine cell fate, but in leukemia these switches are corrupted to promote malignant growth. The Taylor Lab works to define how these transcriptional networks are rewired and how they can be therapeutically redirected to restore healthy function.

Focusing on the art of teaching, the WashU Medicine Teaching Physician Pathway provides residents with advanced training in medical education. During their second and third years, participants join colleagues from multiple departments for sessions on educational theory, curriculum design and teaching techniques, while gaining hands-on experience with medical students and peers in varied settings. Residents also complete a scholarly project in education and have opportunities to present at national conferences, preparing them to become skilled clinician-educators.

Our mission is to increase access to health care for youth who have been disproportionately impacted by HIV, poverty, trauma, and discrimination. In order to protect and promote the physical and mental health of those we serve, we must work together to dismantle institutional racism and injustice to address the root of these conditions.

Investigating early-life origins of liver disease, our laboratory examines how maternal and paternal diet, microbiome shifts and exercise shape offspring liver health. Grounded in the developmental origins hypothesis, we focus on how in utero and perinatal events influence risk for chronic conditions such as non-alcoholic fatty liver disease (NAFLD), with particular emphasis on the impact of parental over-nutrition.

Research profile

Providing personalized support for over 40 years, TLC Family Care connects families with professional nannies, sitters and household helpers. Every caregiver is thoroughly screened for safety and reliability, offering flexible solutions that help you focus on what matters most — your family, career and well-being.