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Defining molecular features driving leukemogenesis to improve outcomes in acute leukemia our lab investigates pathways that differ between malignant and healthy cells, promote chemotherapy resistance and support leukemia stem cell biology. Current projects focus on intracellular metabolism including amino acid and nucleotide metabolism, cellular energetics and polyunsaturated fatty acid metabolism, the unfolded protein response and its role in stress adaptation and mitochondrial regulation critical for cancer cell survival. We also examine how these mechanisms influence healthy hematopoietic stem and progenitor cells to guide rational therapeutic strategies.

Research profile

Exploring how gut microbiota shape disease outcomes, this laboratory investigates microbial influences on pediatric health through genomic sequencing, clinical data and collaborative research. With a focus on gastrointestinal diseases such as necrotizing enterocolitis, projects integrate metagenomics, cohort studies and phylogenetic analysis to uncover microbial drivers of disease and inform future therapeutic strategies.

Research profile

Investigating how pharmacological agents reshape cellular behavior in health and disease, the Taylor Lab at WashU Medicine studies the mechanisms that drive normal and malignant hematopoiesis to improve treatment outcomes for children with cancer. Childhood leukemia arises when genetic mutations disrupt normal blood cell formation and convert healthy cells into cancerous ones, yet major questions remain about how these mutations hijack cellular machinery to sustain disease. Transcription factors — molecular switches that control gene expression — play a central role in this process. In healthy blood development, they guide the programs that determine cell fate, but in leukemia these switches are corrupted to promote malignant growth. The Taylor Lab works to define how these transcriptional networks are rewired and how they can be therapeutically redirected to restore healthy function.

Focusing on the art of teaching, the WashU Medicine Teaching Physician Pathway provides residents with advanced training in medical education. During their second and third years, participants join colleagues from multiple departments for sessions on educational theory, curriculum design and teaching techniques, while gaining hands-on experience with medical students and peers in varied settings. Residents also complete a scholarly project in education and have opportunities to present at national conferences, preparing them to become skilled clinician-educators.

Our mission is to increase access to health care for youth who have been disproportionately impacted by HIV, poverty, trauma, and discrimination. In order to protect and promote the physical and mental health of those we serve, we must work together to dismantle institutional racism and injustice to address the root of these conditions.

Investigating early-life origins of liver disease, our laboratory examines how maternal and paternal diet, microbiome shifts and exercise shape offspring liver health. Grounded in the developmental origins hypothesis, we focus on how in utero and perinatal events influence risk for chronic conditions such as non-alcoholic fatty liver disease (NAFLD), with particular emphasis on the impact of parental over-nutrition.

Research profile

Providing personalized support for over 40 years, TLC Family Care connects families with professional nannies, sitters and household helpers. Every caregiver is thoroughly screened for safety and reliability, offering flexible solutions that help you focus on what matters most — your family, career and well-being.

Making community engagement simple and impactful, STLVolunteer.org links individuals and groups to local organizations in need of support. From one-time projects to ongoing commitments, the platform helps you find ways to give back, build connections and make a difference across the St. Louis region.

Investigating how hormonal changes during pregnancy shape long-term cardiovascular health, our center explores the molecular mechanisms linking gestational hyperandrogenism and exposure to endocrine-disrupting chemicals with adverse maternal and fetal cardio-metabolic outcomes. By integrating large animal models with cellular and molecular biology, we aim to uncover pathways that predispose offspring to cardiovascular disease and identify strategies for prevention and treatment. Our work advances the developmental origins of health and disease framework, driving innovation in early-life interventions.

Research profile