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Exploring molecular mechanisms of neutrophil activation, our laboratory investigates how these critical immune cells shape host defense and influence health and disease. Focusing on the consequences of neutrophil dysregulation, we study its role in driving severe inflammation and contributing to pathology in conditions such as sepsis, organ transplant, acute lung injury and stroke, with the goal of identifying strategies to restore balance and improve patient outcomes.

Research profile

Offering a pathway to leadership in health informatics, the Institute for Informatics, Data Science and Biostatistics, together with the Department of Pediatrics, is pleased to present the Clinical Informatics Fellowship. As one of the newest subspecialties recognized by the American Board of Medical Specialties, clinical informatics focuses on biomedical data, computational systems and clinical process improvement applied to medical practice. The program’s mission is to develop leaders who will advance the field of health informatics.

Providing a centralized resource for studies worldwide, ClinicalTrials.gov helps patients, families and professionals find information on ongoing and completed clinical trials. The platform promotes transparency in research by offering details on eligibility, locations and study objectives to support informed participation and collaboration.

Providing essential guidance for safe and compliant operations, this collection of resources helps faculty, staff and trainees adhere to institutional health, safety and security standards. From laboratory protocols to emergency procedures, these materials are designed to support a culture of responsibility and ensure that all activities meet regulatory and institutional requirements.

Focusing on the environmental and genetic origins of congenital heart and vascular disorders, our center is committed to advancing understanding of birth defects and related heart conditions. By integrating cutting-edge research with collaborative partnerships, we aim to uncover mechanisms that drive these diseases and translate discoveries into improved diagnostics and therapies for patients of all ages.

Investigating the origins of immune-mediated disorders in children, the Cooper lab focuses on uncovering genetic mechanisms that contribute to pediatric immune dysregulation. Using advanced genomic sequencing, we identify genetic causes of disease and employ both in vitro and in vivo models to deepen understanding of these conditions. Our work emphasizes leveraging cutting-edge sequencing technologies to reveal mechanisms underlying undiagnosed immune deficiencies in children.

Research profile

Empowering research through shared expertise and advanced technology, WashU’s core facilities provide investigators with access to specialized equipment, services and technical support. These centralized resources enable high-quality, cost-effective research across disciplines, fostering collaboration and innovation from basic science to clinical applications.

Providing expert care for critically ill children St. Louis Children’s Hospital offers specialized cardiac, pediatric and neurocritical care. Our teams deliver advanced treatment in dedicated intensive care units and provide follow-up programs to support recovery and long-term well-being.

Harnessing advanced technology and multidisciplinary expertise, we deliver compassionate, evidence-based care for children in intensive care settings. Our team is committed to improving outcomes through cutting-edge research, rigorous training and a patient-centered approach that supports families during the most challenging moments.

Preparing graduates for rewarding careers in pediatric critical care medicine, this ACGME-accredited program supports fellows in exploring their individual clinical and academic interests while building a strong foundation of knowledge and experience. The program admits five fellows per year and participates in the NRMP Match for pediatric critical care medicine.